FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3152018805> ?p ?o ?g. }

• W3152018805 endingPage "3423" @default.
• W3152018805 startingPage "3411" @default.
• W3152018805 abstract "Injectable bone cement is especially useful in minimally invasive surgeries to repair small and irregular bone defects. Amongst different kinds of injectable bone cements, bioactive calcium phosphate bone cement (CPC) has been widely studied due to its biological activity. However, its dense structure and poor biodegradability prevent the ingrowth of living tissue, which leads to undesirable bone regeneration and clinical translation. To address this issue, we prepared bone cement based on Magnesium-containing microspheres (MMSs) that can not only be cured into a 3D porous scaffold but also have controllable biodegradability that continuously provides space for desired tissue ingrowth. Interestingly, magnesium ions released from MMSs cement (MMSC) trigger positive immunomodulation via upregulation of the anti-inflammatory genes IL-10 and M2 macrophage polarization with increased expression of CD206, which is beneficial to osteogenesis. Moreover, the physicochemical properties of MMSC, including heat release, rheology and setting time, can be tuned to meet the requirements of injectable bone cement for clinical application. Using a rat model, we have demonstrated that MMSC promoted osteogenesis via mediation of tissue ingrowth and anti-inflammatory immunomodulation. The study provides a paradigm for the design and preparation of injectable bone cements with 3D porous structures, biodegradability and anti-inflammatory immunoregulation to efficiently promote osteogenesis. • Magnesium containing microspheres (MMSs) were prepared successfully by a modified liquid drop condensation method. • MMSs cement had 3D porous structure with biodegradability and anti-inflammatory osteoimmunomodulation mediated by the Mg 2+ . • A new strategy was provided for the design and preparation of novel injectable bone cements with desired osteogenesis." @default.
• W3152018805 created "2021-04-13" @default.
• W3152018805 creator A5039676407 @default.
• W3152018805 creator A5051762810 @default.
• W3152018805 creator A5063594000 @default.
• W3152018805 creator A5086752003 @default.
• W3152018805 creator A5088899944 @default.
• W3152018805 date "2021-10-01" @default.
• W3152018805 modified "2023-10-10" @default.
• W3152018805 title "Injectable bone cement with magnesium-containing microspheres enhances osteogenesis via anti-inflammatory immunoregulation" @default.
• W3152018805 cites W1535838746 @default.
• W3152018805 cites W1953179980 @default.
• W3152018805 cites W1971897579 @default.
• W3152018805 cites W1979432868 @default.
• W3152018805 cites W1980599128 @default.
• W3152018805 cites W1986425697 @default.
• W3152018805 cites W1987444815 @default.
• W3152018805 cites W1991139319 @default.
• W3152018805 cites W1993454360 @default.
• W3152018805 cites W1995063875 @default.
• W3152018805 cites W1996760356 @default.
• W3152018805 cites W2011634501 @default.
• W3152018805 cites W2028025792 @default.
• W3152018805 cites W2028548404 @default.
• W3152018805 cites W2041209013 @default.
• W3152018805 cites W2043525625 @default.
• W3152018805 cites W2052588727 @default.
• W3152018805 cites W2055671797 @default.
• W3152018805 cites W2124672774 @default.
• W3152018805 cites W2126051452 @default.
• W3152018805 cites W2149250436 @default.
• W3152018805 cites W2194806179 @default.
• W3152018805 cites W2291522985 @default.
• W3152018805 cites W2521867133 @default.
• W3152018805 cites W2613275913 @default.
• W3152018805 cites W2887881034 @default.
• W3152018805 cites W2909537306 @default.
• W3152018805 cites W3005680729 @default.
• W3152018805 cites W3014818537 @default.
• W3152018805 cites W3085546928 @default.
• W3152018805 doi "https://doi.org/10.1016/j.bioactmat.2021.03.006" @default.
• W3152018805 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/8010581" @default.
• W3152018805 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/33842737" @default.
• W3152018805 hasPublicationYear "2021" @default.
• W3152018805 type Work @default.
• W3152018805 sameAs 3152018805 @default.
• W3152018805 citedByCount "45" @default.
• W3152018805 countsByYear W31520188052021 @default.
• W3152018805 countsByYear W31520188052022 @default.
• W3152018805 countsByYear W31520188052023 @default.
• W3152018805 crossrefType "journal-article" @default.
• W3152018805 hasAuthorship W3152018805A5039676407 @default.
• W3152018805 hasAuthorship W3152018805A5051762810 @default.
• W3152018805 hasAuthorship W3152018805A5063594000 @default.
• W3152018805 hasAuthorship W3152018805A5086752003 @default.
• W3152018805 hasAuthorship W3152018805A5088899944 @default.
• W3152018805 hasBestOaLocation W31520188051 @default.
• W3152018805 hasConcept C136229726 @default.
• W3152018805 hasConcept C141071460 @default.
• W3152018805 hasConcept C157021035 @default.
• W3152018805 hasConcept C159985019 @default.
• W3152018805 hasConcept C178790620 @default.
• W3152018805 hasConcept C185592680 @default.
• W3152018805 hasConcept C191897082 @default.
• W3152018805 hasConcept C192562407 @default.
• W3152018805 hasConcept C2777230088 @default.
• W3152018805 hasConcept C2778606738 @default.
• W3152018805 hasConcept C2778891590 @default.
• W3152018805 hasConcept C42820424 @default.
• W3152018805 hasConcept C523993062 @default.
• W3152018805 hasConcept C71924100 @default.
• W3152018805 hasConcept C8337478 @default.
• W3152018805 hasConcept C89429830 @default.
• W3152018805 hasConceptScore W3152018805C136229726 @default.
• W3152018805 hasConceptScore W3152018805C141071460 @default.
• W3152018805 hasConceptScore W3152018805C157021035 @default.
• W3152018805 hasConceptScore W3152018805C159985019 @default.
• W3152018805 hasConceptScore W3152018805C178790620 @default.
• W3152018805 hasConceptScore W3152018805C185592680 @default.
• W3152018805 hasConceptScore W3152018805C191897082 @default.
• W3152018805 hasConceptScore W3152018805C192562407 @default.
• W3152018805 hasConceptScore W3152018805C2777230088 @default.
• W3152018805 hasConceptScore W3152018805C2778606738 @default.
• W3152018805 hasConceptScore W3152018805C2778891590 @default.
• W3152018805 hasConceptScore W3152018805C42820424 @default.
• W3152018805 hasConceptScore W3152018805C523993062 @default.
• W3152018805 hasConceptScore W3152018805C71924100 @default.
• W3152018805 hasConceptScore W3152018805C8337478 @default.
• W3152018805 hasConceptScore W3152018805C89429830 @default.
• W3152018805 hasIssue "10" @default.
• W3152018805 hasLocation W31520188051 @default.
• W3152018805 hasLocation W31520188052 @default.
• W3152018805 hasLocation W31520188053 @default.
• W3152018805 hasLocation W31520188054 @default.
• W3152018805 hasOpenAccess W3152018805 @default.
• W3152018805 hasPrimaryLocation W31520188051 @default.
• W3152018805 hasRelatedWork W2050363822 @default.
• W3152018805 hasRelatedWork W2559081809 @default.

• next