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- W3152143119 abstract "The Author(s) 2013. This article is published with open access at Springerlink.com Abstract To analyze the levels of oxidized low density lipoprotein (ox-LDL) and inflammatory cytokines in the plasma of gout patients. The levels of ox-LDL, hypersen- sitive C-reactive protein (hs-CRP), interleukin-1b, inter- leukin-6 (IL-6) and tumor necrosis factor-a (TNF-a) were measured in the plasma of 41 gout patients (28 in acute phase episode, 13 in intermittent phase (IP)), and in 40 healthy controls. The relationship between ox-LDL and inflammation was also explored by measuring the levels of several pro-inflammatory cytokines in the plasma. The plasma levels of ox-LDL, hs-CRP, IL-6 and TNF-a were significantly increased in patients with gout in the acute phase compared to those in the IP group and healthy controls (P 0.05), but the levels of TGF-b were signifi- cantly lower in the acute phase group than in the IP group and healthy controls (P 0.01). The levels of ox-LDL in the gout patients in the IP were significantly higher than those in healthy controls (P 0.05). Correlation analysis indicated that the levels of ox-LDL were positively corre- lated with hs-CRP, IL-6 and TNF-a (r = 0.343, r = 0.386, r = 0.659, P 0.01, respectively), but negatively corre- lated with TGF-b levels in patients in the acute phase (r =- 0.240, P 0.05). The levels of ox-LDL in gout patients were significantly higher than those in healthy controls. The changes in ox-LDL levels may be associated with enhanced inflammation in gout patients." @default.
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- W3152143119 date "2014-01-01" @default.
- W3152143119 modified "2023-09-23" @default.
- W3152143119 title "Oxidized Low Density Lipoprotein and Inflammation in Gout Patients" @default.
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