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- W3152144315 abstract "] AIM: To study the hydroxylation in glycyrrhetinic acid (GA) by biocatalysis, and evaluate the antibacterial activities of the derivatives. METHODS: The hydroxylation was performed via incubating GA with a fungus, Cunninghamella blakesleeana (C. blakesleeana) AS 3.970 at 30 °C for 5 days. RESULTS: GA was converted into two major derivatives and four minor derivatives. The two major derivatives were isolated and elucidated as 3-oxo-7β-hydroxy-glycyrrhetinic acid (GA-1) and 7β-hydroxy-glycyrrhetinic acid (GA-2) based on their spectral data, and other derivatives (GA-3–GA-6) were identified by HR-ESI-MS. The antibacterial activi- ties of substrate and two major derivatives were evaluated on four bacteria strains and one yeast strain. CONCLUSION: Cunning- hamella blakesleeana AS 3.970 has the capability of hydroxylation for GA. The two major derivatives and GA were found to have considerable activities against drug-resistant Enterococcus faecalis. [" @default.
- W3152144315 created "2021-04-13" @default.
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- W3152144315 date "2010-01-01" @default.
- W3152144315 modified "2023-09-26" @default.
- W3152144315 title "Biotransformation of Glycyrrhetinic Acid by Cunninghamella blakesleeana" @default.
- W3152144315 hasPublicationYear "2010" @default.
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