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- W3152147864 endingPage "348" @default.
- W3152147864 startingPage "340" @default.
- W3152147864 abstract "Tauopathies are a group of neurodegenerative diseases that involve pathological changes to the tau protein. Neuroinflammation is a commonly reported feature of tauopathies that has been demonstrated to exacerbate tau pathology and, hence, neurodegeneration. Microglia can mediate the inflammatory response in order to maintain brain homeostasis. In the aged brain, microglia are reported to undergo morphological and functional changes, adopting a pro-inflammatory profile and loss of homeostatic functions. Dystrophic and dysfunctional microglia are associated with tau pathology in the healthy and diseased brain which is proposed to contribute to disease development and progression. Microglia have also been recently demonstrated to possess sexually dimorphic roles in the developing, adult and aged brain. The sex differences in microglial functionality suggest that microglia may contribute to tauopathies which may differ between sexes. This review highlights the detrimental loop between age-related microglial changes and tau pathology with implications for microglial sexual dichotomy." @default.
- W3152147864 created "2021-04-13" @default.
- W3152147864 creator A5034875769 @default.
- W3152147864 creator A5068139538 @default.
- W3152147864 creator A5084569574 @default.
- W3152147864 date "2021-09-01" @default.
- W3152147864 modified "2023-10-06" @default.
- W3152147864 title "Implications for microglial sex differences in tau-related neurodegenerative diseases" @default.
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