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- W3152163923 abstract "Objective:To explore of the role of JNK/SAPK signal transduction system in the apoptosis of human leukemic cell lines Jurkat and U937 induced by anti-human DR5 monoclonal antibody mDRA-6.Methods:Human leukemic cell lines Jurkat and U937 were treated with different concentrations of mDRA-6.MTT assay was used to observe the proliferation of Jurkat and U937cells,and Flow cytometry was used to examine apoptosis rate before and after JNK signal was blocked by SP600125,a JNK inhibitor.The expression of p-JNK was detected by Western blot.Results:mDRA-6 inhibited the proliferation of Jurkat and U937 cells in a concentration-and time-dependent manner.Flow cytometry showed that mDRA-6 induced the apoptosis of Jurkat and U937 cells,while the apoptosis rate was increased after JNK signal was blocked by SP600125,a JNK inhibitor.Western blot exhibited that mDRA-6 induced the activation of p-JNK.The expression of p-JNK was detected 5 minutes after mDRA-6 treatment,while the activation of p-JNK was gradually suppressed after Caspase inhibitor Z-VAD-FMK treatment.Conclusion:mDRA-6 can inhibit the proliferation and induce the apoptosis of leukemic cell lines Jurkat and U937 in vitro.mDRA-6-induced apoptosis activated p-JNK,SP600125 inhibits the activation of JNK,and therefore increases the apoptosis rate of Jurkat and U937 cells induced by mDRA-6." @default.
- W3152163923 created "2021-04-13" @default.
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- W3152163923 date "2009-01-01" @default.
- W3152163923 modified "2023-09-28" @default.
- W3152163923 title "The role of c-jun N-terminal Kinase (JNK) signaling pathway in the apoptosis of leukemic cells induced by anti-human DR5 monoclonal antibody mDRA-6" @default.
- W3152163923 hasPublicationYear "2009" @default.
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