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- W3152165975 abstract "Dear Editor, As the patents of original biological drugs expire, biosimilar agents may replace the originators. These agents are designed to have similar molecular structures, efficacy and safety profiles to the licensed bio-originators [1]. In real-world patients, clinical effectiveness is still debated. The rarer side effect profiles of the originators are emerging, though occurrences are yet to be seen with biosimilars [2]. We present the first report in the literature of pyoderma gangrenosum induced by biosimilar adalimumab in a patient with seropositive rheumatoid arthritis. A 48-year-old gentleman had a long-standing history of seropositive rheumatoid arthritis. His disease activity remained high despite being on injectable methotrexate 20 mg weekly and hydroxychloroquine 200 mg daily. A decision was made to commence biosimilar adalimumab 40 mg every other week, in addition to methotrexate and hydroxychloroquine. After two doses of adalimumab, he developed multiple blisters and ulcers on both..." @default.
- W3152165975 created "2021-04-13" @default.
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- W3152165975 date "2021-04-09" @default.
- W3152165975 modified "2023-09-30" @default.
- W3152165975 title "Pyoderma gangrenosum induced by adalimumab in a seropositive rheumatoid arthritis patient: a paradoxical effect of adalimumab?" @default.
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- W3152165975 doi "https://doi.org/10.1093/rheumatology/keab194" @default.
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