FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3152196043> ?p ?o ?g. }

• W3152196043 endingPage "119023" @default.
• W3152196043 startingPage "119023" @default.
• W3152196043 abstract "Changes in cytosolic free Ca2+ concentration play a central role in many fundamental cellular processes including muscle contraction, neurotransmission, cell proliferation, differentiation, gene transcription and cell death. Many of these processes are known to be regulated by store-operated calcium channels (SOCs), among which ORAI1 is the most studied in cancer cells, leaving the role of other ORAI channels yet inadequately addressed. Here we demonstrate that ORAI3 channels are expressed in both normal (HPDE) and pancreatic ductal adenocarcinoma (PDAC) cell lines, where they form functional channels, their knockdown affecting store operated calcium entry (SOCE). More specifically, ORAI3 silencing increased SOCE in PDAC cell lines, while decreasing SOCE in normal pancreatic cell line. We also show the role of ORAI3 in proliferation, cell cycle, viability, mitotic catastrophe and cell death. Finally, we demonstrate that ORAI3 silencing impairs pancreatic tumor growth and induces cell death in vivo, suggesting that ORAI3 could represent a potential therapeutic target in PDAC treatment." @default.
• W3152196043 created "2021-04-13" @default.
• W3152196043 creator A5007220163 @default.
• W3152196043 creator A5015143100 @default.
• W3152196043 creator A5027911156 @default.
• W3152196043 creator A5028323461 @default.
• W3152196043 creator A5034600603 @default.
• W3152196043 creator A5045487233 @default.
• W3152196043 creator A5050432911 @default.
• W3152196043 creator A5052280566 @default.
• W3152196043 creator A5053887359 @default.
• W3152196043 creator A5069476958 @default.
• W3152196043 creator A5070480765 @default.
• W3152196043 creator A5052570336 @default.
• W3152196043 date "2021-06-01" @default.
• W3152196043 modified "2023-10-01" @default.
• W3152196043 title "ORAI3 silencing alters cell proliferation and promotes mitotic catastrophe and apoptosis in pancreatic adenocarcinoma" @default.
• W3152196043 cites W1495215957 @default.
• W3152196043 cites W1963703355 @default.
• W3152196043 cites W1981577795 @default.
• W3152196043 cites W2015331270 @default.
• W3152196043 cites W2041383551 @default.
• W3152196043 cites W2059038663 @default.
• W3152196043 cites W2085242011 @default.
• W3152196043 cites W2085269717 @default.
• W3152196043 cites W2087152030 @default.
• W3152196043 cites W2091352240 @default.
• W3152196043 cites W2100239923 @default.
• W3152196043 cites W2101586949 @default.
• W3152196043 cites W2115715486 @default.
• W3152196043 cites W2137258759 @default.
• W3152196043 cites W2146664668 @default.
• W3152196043 cites W2152775147 @default.
• W3152196043 cites W2176757944 @default.
• W3152196043 cites W2625835005 @default.
• W3152196043 cites W2785885120 @default.
• W3152196043 cites W2800335290 @default.
• W3152196043 cites W2889646458 @default.
• W3152196043 cites W2972602909 @default.
• W3152196043 cites W2996375815 @default.
• W3152196043 cites W3009903374 @default.
• W3152196043 cites W3011079318 @default.
• W3152196043 cites W3024569254 @default.
• W3152196043 doi "https://doi.org/10.1016/j.bbamcr.2021.119023" @default.
• W3152196043 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/33798603" @default.
• W3152196043 hasPublicationYear "2021" @default.
• W3152196043 type Work @default.
• W3152196043 sameAs 3152196043 @default.
• W3152196043 citedByCount "9" @default.
• W3152196043 countsByYear W31521960432021 @default.
• W3152196043 countsByYear W31521960432022 @default.
• W3152196043 countsByYear W31521960432023 @default.
• W3152196043 crossrefType "journal-article" @default.
• W3152196043 hasAuthorship W3152196043A5007220163 @default.
• W3152196043 hasAuthorship W3152196043A5015143100 @default.
• W3152196043 hasAuthorship W3152196043A5027911156 @default.
• W3152196043 hasAuthorship W3152196043A5028323461 @default.
• W3152196043 hasAuthorship W3152196043A5034600603 @default.
• W3152196043 hasAuthorship W3152196043A5045487233 @default.
• W3152196043 hasAuthorship W3152196043A5050432911 @default.
• W3152196043 hasAuthorship W3152196043A5052280566 @default.
• W3152196043 hasAuthorship W3152196043A5052570336 @default.
• W3152196043 hasAuthorship W3152196043A5053887359 @default.
• W3152196043 hasAuthorship W3152196043A5069476958 @default.
• W3152196043 hasAuthorship W3152196043A5070480765 @default.
• W3152196043 hasBestOaLocation W31521960432 @default.
• W3152196043 hasConcept C104317684 @default.
• W3152196043 hasConcept C119056186 @default.
• W3152196043 hasConcept C1491633281 @default.
• W3152196043 hasConcept C190283241 @default.
• W3152196043 hasConcept C29537977 @default.
• W3152196043 hasConcept C31573885 @default.
• W3152196043 hasConcept C502942594 @default.
• W3152196043 hasConcept C54355233 @default.
• W3152196043 hasConcept C55493867 @default.
• W3152196043 hasConcept C62112901 @default.
• W3152196043 hasConcept C86803240 @default.
• W3152196043 hasConcept C93304396 @default.
• W3152196043 hasConcept C95444343 @default.
• W3152196043 hasConceptScore W3152196043C104317684 @default.
• W3152196043 hasConceptScore W3152196043C119056186 @default.
• W3152196043 hasConceptScore W3152196043C1491633281 @default.
• W3152196043 hasConceptScore W3152196043C190283241 @default.
• W3152196043 hasConceptScore W3152196043C29537977 @default.
• W3152196043 hasConceptScore W3152196043C31573885 @default.
• W3152196043 hasConceptScore W3152196043C502942594 @default.
• W3152196043 hasConceptScore W3152196043C54355233 @default.
• W3152196043 hasConceptScore W3152196043C55493867 @default.
• W3152196043 hasConceptScore W3152196043C62112901 @default.
• W3152196043 hasConceptScore W3152196043C86803240 @default.
• W3152196043 hasConceptScore W3152196043C93304396 @default.
• W3152196043 hasConceptScore W3152196043C95444343 @default.
• W3152196043 hasFunder F4320320893 @default.
• W3152196043 hasFunder F4320322363 @default.
• W3152196043 hasFunder F4320322646 @default.
• W3152196043 hasFunder F4320322727 @default.
• W3152196043 hasFunder F4320326227 @default.
• W3152196043 hasIssue "7" @default.

• next