Matches in SemOpenAlex for { <https://semopenalex.org/work/W3152202330> ?p ?o ?g. }
Showing items 1 to 76 of
76
with 100 items per page.
- W3152202330 endingPage "513" @default.
- W3152202330 startingPage "509" @default.
- W3152202330 abstract "Accumulating evidence has shown that allogeneic blood transfusions can induce significant immunosuppression in recipients, and thereby increase the risk of postoperative infection and/or tumor relapse. Although it is well known that natural killer(NK) cells are responsible for the immunodepression effects of transfusion, the underlying mechanisms remain obscure. In this study, we investigated the role of NK cells in transfusion-induced immunodepression in β-thalassemia major. The proportion of circulating NK cells and the expression of NK receptors(NKG2A, CD158 a, NKP30, NKP46 and NKG2D) as well as CD107 a were detected by multicolor flow cytometry. IFN-γ production by circulating NK cells was detected by intracellular cytokine staining. Our results showed that the proportion and cytotoxicity(CD107a expression) of circulating NK cells in transfusion-dependent β-thalassemia major patients were remarkably lower than those of β-thalassemia minor patients or healthy volunteers. Expression of NKG2 A inhibitory receptor on circulating NK cells in patients with β-thalassemia major was remarkably up-regulated, but there were no significant differences in the expression levels of NKP30, NKP46, NKG2 D, CD158 a and IFN-γ. These results indicate NKG2 A inhibitory receptor may play a key role in transfusion-induced immunodepression of NK cells in patients with β-thalassemia major." @default.
- W3152202330 created "2021-04-13" @default.
- W3152202330 creator A5000844043 @default.
- W3152202330 creator A5023977586 @default.
- W3152202330 creator A5030156264 @default.
- W3152202330 creator A5037185048 @default.
- W3152202330 creator A5040240984 @default.
- W3152202330 creator A5067389210 @default.
- W3152202330 creator A5091837632 @default.
- W3152202330 date "2016-01-01" @default.
- W3152202330 modified "2023-09-24" @default.
- W3152202330 title "Up-regulation of NKG2A Inhibitory Receptor on Circulating NK Cells Contributes to Transfusion-induced Immunodepression in Patients with β-thalassemia Major" @default.
- W3152202330 hasPublicationYear "2016" @default.
- W3152202330 type Work @default.
- W3152202330 sameAs 3152202330 @default.
- W3152202330 citedByCount "0" @default.
- W3152202330 crossrefType "journal-article" @default.
- W3152202330 hasAuthorship W3152202330A5000844043 @default.
- W3152202330 hasAuthorship W3152202330A5023977586 @default.
- W3152202330 hasAuthorship W3152202330A5030156264 @default.
- W3152202330 hasAuthorship W3152202330A5037185048 @default.
- W3152202330 hasAuthorship W3152202330A5040240984 @default.
- W3152202330 hasAuthorship W3152202330A5067389210 @default.
- W3152202330 hasAuthorship W3152202330A5091837632 @default.
- W3152202330 hasConcept C109316439 @default.
- W3152202330 hasConcept C170493617 @default.
- W3152202330 hasConcept C202751555 @default.
- W3152202330 hasConcept C203014093 @default.
- W3152202330 hasConcept C2777799968 @default.
- W3152202330 hasConcept C2778867473 @default.
- W3152202330 hasConcept C2780252810 @default.
- W3152202330 hasConcept C54355233 @default.
- W3152202330 hasConcept C553184892 @default.
- W3152202330 hasConcept C55493867 @default.
- W3152202330 hasConcept C86803240 @default.
- W3152202330 hasConceptScore W3152202330C109316439 @default.
- W3152202330 hasConceptScore W3152202330C170493617 @default.
- W3152202330 hasConceptScore W3152202330C202751555 @default.
- W3152202330 hasConceptScore W3152202330C203014093 @default.
- W3152202330 hasConceptScore W3152202330C2777799968 @default.
- W3152202330 hasConceptScore W3152202330C2778867473 @default.
- W3152202330 hasConceptScore W3152202330C2780252810 @default.
- W3152202330 hasConceptScore W3152202330C54355233 @default.
- W3152202330 hasConceptScore W3152202330C553184892 @default.
- W3152202330 hasConceptScore W3152202330C55493867 @default.
- W3152202330 hasConceptScore W3152202330C86803240 @default.
- W3152202330 hasIssue "4" @default.
- W3152202330 hasLocation W31522023301 @default.
- W3152202330 hasOpenAccess W3152202330 @default.
- W3152202330 hasPrimaryLocation W31522023301 @default.
- W3152202330 hasRelatedWork W1480838044 @default.
- W3152202330 hasRelatedWork W1969035614 @default.
- W3152202330 hasRelatedWork W2055749857 @default.
- W3152202330 hasRelatedWork W2111182680 @default.
- W3152202330 hasRelatedWork W2115869326 @default.
- W3152202330 hasRelatedWork W2220905033 @default.
- W3152202330 hasRelatedWork W2496060709 @default.
- W3152202330 hasRelatedWork W2538486741 @default.
- W3152202330 hasRelatedWork W2552554758 @default.
- W3152202330 hasRelatedWork W2556633626 @default.
- W3152202330 hasRelatedWork W2561504127 @default.
- W3152202330 hasRelatedWork W2572311492 @default.
- W3152202330 hasRelatedWork W2588012638 @default.
- W3152202330 hasRelatedWork W2754356861 @default.
- W3152202330 hasRelatedWork W2799939579 @default.
- W3152202330 hasRelatedWork W2802418748 @default.
- W3152202330 hasRelatedWork W2908170468 @default.
- W3152202330 hasRelatedWork W3033713777 @default.
- W3152202330 hasRelatedWork W3154660514 @default.
- W3152202330 hasRelatedWork W3164904236 @default.
- W3152202330 isParatext "false" @default.
- W3152202330 isRetracted "false" @default.
- W3152202330 magId "3152202330" @default.
- W3152202330 workType "article" @default.