Matches in SemOpenAlex for { <https://semopenalex.org/work/W3152202866> ?p ?o ?g. }
Showing items 1 to 92 of
92
with 100 items per page.
- W3152202866 endingPage "S230" @default.
- W3152202866 startingPage "S230" @default.
- W3152202866 abstract "Introduction: We attempted to build a clinical model to predict the prognosis of PDAC patients by the quantification of the lncRNA and explore the biofunctional mechanism. Method: We downloaded RNA-Seq profiles from the TCGA and GTEx databases of PDAC patients and normal samples. Moreover, we identified the differential expression lncRNAs, and used the K-M curves, the univariate Cox analysis, the lasso regression model, and the hierarchical clustering to establish a pancreatic cancer risk assessment model. Finally, GO and KEGG analyses were conducted to explore the underlying mechanism of the lncRNAs. Results: We found that the low expression of LncRNA AC093010.3, LINC01089, AL049840.4, AC005261.1, and high expression of AL513314.2, UNC5B-AS1 are associated with PDAC patients´ poor prognosis. Every PDAC patient with lncRNA quantitation produced a risk score and will be divided into different groups. High-risk group two-year OS is 21.28% (vs. low-risk group is 49.32%), and the five-year OS is 9.12% (vs. low-risk group is 28.77%). The AUC of the ROC curve was 0.747. The hierarchical clustering divided patients into two clusters derived for RNA-Seq, and samples in the UNC5B-AS1 enriched cluster had significantly worse OS than patients in the AC093010.3 upregurated cluster (median OS of 15.8 months vs. 20.3 months, p=0.008). The GO and KEGG analyses showed that the most significant biological function is cell adhesion molecule binding, while the cell cycle pathway was the core pathway of the entire prognostic model. Conclusions: We constructed a reliable prognostic model for pancreatic cancer and identified potential therapeutic targets of lncRNA." @default.
- W3152202866 created "2021-04-13" @default.
- W3152202866 creator A5000986155 @default.
- W3152202866 creator A5008750923 @default.
- W3152202866 creator A5008975931 @default.
- W3152202866 creator A5021361625 @default.
- W3152202866 creator A5032436700 @default.
- W3152202866 creator A5034262385 @default.
- W3152202866 creator A5045916433 @default.
- W3152202866 creator A5057701440 @default.
- W3152202866 creator A5080256448 @default.
- W3152202866 date "2021-01-01" @default.
- W3152202866 modified "2023-10-14" @default.
- W3152202866 title "The satan's apple: LncRNAs play the critical role of pancreatic ductal adenocarcinoma" @default.
- W3152202866 doi "https://doi.org/10.1016/j.hpb.2020.11.576" @default.
- W3152202866 hasPublicationYear "2021" @default.
- W3152202866 type Work @default.
- W3152202866 sameAs 3152202866 @default.
- W3152202866 citedByCount "0" @default.
- W3152202866 crossrefType "journal-article" @default.
- W3152202866 hasAuthorship W3152202866A5000986155 @default.
- W3152202866 hasAuthorship W3152202866A5008750923 @default.
- W3152202866 hasAuthorship W3152202866A5008975931 @default.
- W3152202866 hasAuthorship W3152202866A5021361625 @default.
- W3152202866 hasAuthorship W3152202866A5032436700 @default.
- W3152202866 hasAuthorship W3152202866A5034262385 @default.
- W3152202866 hasAuthorship W3152202866A5045916433 @default.
- W3152202866 hasAuthorship W3152202866A5057701440 @default.
- W3152202866 hasAuthorship W3152202866A5080256448 @default.
- W3152202866 hasBestOaLocation W31522028661 @default.
- W3152202866 hasConcept C104317684 @default.
- W3152202866 hasConcept C112930515 @default.
- W3152202866 hasConcept C119857082 @default.
- W3152202866 hasConcept C121608353 @default.
- W3152202866 hasConcept C126322002 @default.
- W3152202866 hasConcept C143998085 @default.
- W3152202866 hasConcept C150194340 @default.
- W3152202866 hasConcept C152724338 @default.
- W3152202866 hasConcept C162317418 @default.
- W3152202866 hasConcept C2780210213 @default.
- W3152202866 hasConcept C2986432223 @default.
- W3152202866 hasConcept C2992026798 @default.
- W3152202866 hasConcept C41008148 @default.
- W3152202866 hasConcept C50382708 @default.
- W3152202866 hasConcept C54355233 @default.
- W3152202866 hasConcept C60644358 @default.
- W3152202866 hasConcept C70721500 @default.
- W3152202866 hasConcept C71924100 @default.
- W3152202866 hasConcept C73555534 @default.
- W3152202866 hasConcept C86803240 @default.
- W3152202866 hasConcept C92835128 @default.
- W3152202866 hasConceptScore W3152202866C104317684 @default.
- W3152202866 hasConceptScore W3152202866C112930515 @default.
- W3152202866 hasConceptScore W3152202866C119857082 @default.
- W3152202866 hasConceptScore W3152202866C121608353 @default.
- W3152202866 hasConceptScore W3152202866C126322002 @default.
- W3152202866 hasConceptScore W3152202866C143998085 @default.
- W3152202866 hasConceptScore W3152202866C150194340 @default.
- W3152202866 hasConceptScore W3152202866C152724338 @default.
- W3152202866 hasConceptScore W3152202866C162317418 @default.
- W3152202866 hasConceptScore W3152202866C2780210213 @default.
- W3152202866 hasConceptScore W3152202866C2986432223 @default.
- W3152202866 hasConceptScore W3152202866C2992026798 @default.
- W3152202866 hasConceptScore W3152202866C41008148 @default.
- W3152202866 hasConceptScore W3152202866C50382708 @default.
- W3152202866 hasConceptScore W3152202866C54355233 @default.
- W3152202866 hasConceptScore W3152202866C60644358 @default.
- W3152202866 hasConceptScore W3152202866C70721500 @default.
- W3152202866 hasConceptScore W3152202866C71924100 @default.
- W3152202866 hasConceptScore W3152202866C73555534 @default.
- W3152202866 hasConceptScore W3152202866C86803240 @default.
- W3152202866 hasConceptScore W3152202866C92835128 @default.
- W3152202866 hasLocation W31522028661 @default.
- W3152202866 hasOpenAccess W3152202866 @default.
- W3152202866 hasPrimaryLocation W31522028661 @default.
- W3152202866 hasRelatedWork W2132783153 @default.
- W3152202866 hasRelatedWork W2136627088 @default.
- W3152202866 hasRelatedWork W2551839783 @default.
- W3152202866 hasRelatedWork W3117543481 @default.
- W3152202866 hasRelatedWork W3128941837 @default.
- W3152202866 hasRelatedWork W3165794028 @default.
- W3152202866 hasRelatedWork W3179056284 @default.
- W3152202866 hasRelatedWork W3200763748 @default.
- W3152202866 hasRelatedWork W4253543805 @default.
- W3152202866 hasRelatedWork W4292448967 @default.
- W3152202866 hasVolume "23" @default.
- W3152202866 isParatext "false" @default.
- W3152202866 isRetracted "false" @default.
- W3152202866 magId "3152202866" @default.
- W3152202866 workType "article" @default.