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- W3152237129 abstract "Objective To elucidate the role of platelet derived growth factor B(PDGFB)and platelet derived growth factor receptor β(PDGFRβ) in vascular angiogenesis and remodeling in the mouse model of asthma.Methods After establish ment of the mouse model of bronchial asthma,immunofluorescence and HE staining were used to count the number of vascular smooth muscle cells(vSMC),then reverse transcription-polymerase chain reaction(RT-PCR)and western blot methods were used to detect mRNA and protein level of PDGFB and PDGFRβ in trachea and lung tissues.Results ①Smooth muscle cells decreased in acute phase,however,they returned to nearly normal in chronic stage;②PDGFB mRNA and PDGFRβ mRNA were not detected in normal tracheal tissue.But they were increased in trachea in chronic asthma.They showed enhanced expressions in asthma lung tissues compared with those in normal tissues,especially in chronic phase.The results of protein levels using western blot method were consistent with mRNA expression.Conclusions PDGFB and PDGFRβ mRNA and protein showed enhanced expressions in asthma tracheal and lung tissues compared with those in normal tissues,especially in chronic phase.This is a main factor of vSMC changes.PDGFB and PDGFRβ may play an important role in vascular angiogenesis and remodeling in asthma murine model.Key words: Bronchial asthma; Vascular smooth muscle cells; Platelet derived growth factor" @default.
- W3152237129 created "2021-04-13" @default.
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- W3152237129 date "2008-05-05" @default.
- W3152237129 modified "2023-09-26" @default.
- W3152237129 title "Platelet derived growth factor B and its receptor β in airway vascular angiogenesis and remodeling in a murine model of bronchial asthma" @default.
- W3152237129 doi "https://doi.org/10.3760/cma.j.issn.1673-436x.2008.09.001" @default.
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