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- W3152256148 abstract "This research was to prepare ramipril loaded solid lipidnanoparticles for controlled release of drug and a trial to improve the bioavailability.Hot homogenization and ultrasound dispersion were employed to produce SLNsusing biodegradable lipids and non ionic surfactants.The formulated SLNs were characterized for entrapment efficiency, particle sizeand in vitro release studies in phosphate buffer saline PH 7.4.The nanoparticle colloidal drug delivery system of ramipril prepared type oflipids and non ionic surfactants obtained better entrapment efficiency.The better entrapment efficiency of SLNs was obtained with more hydrophilicsurfactants (poloxamer 188) about 85.36% due to the higher HLB value of thesurfactant.The results revealed that the increase in the surfactant concentration increasesthe entrapment efficiency for all formulations and the percentage entrapment efficiencyof various non ionic surfactants was observed in the order of Poloxamer 188 > Tween80 > Span 20.The particle size of the formulated ramipril SLNs exhibited nanometer sizerange spherical shape particles.The in vitro release studies revealed that the SLN formulations showed aprolonged drug release.SEM analysis of the SLN dispersion showed the spherical shape of thenanoparticles.Stability studies indicated that the entrapment efficiency of the SLN was notaffected significantly in the refrigerated storage temperature. However there may be a slight reduction in the entrapment efficiency of the SLN due to the drug expulsion fromthe crystal lattice.The results of the IR studies proved that no interactions between the drug, lipidand formulations.It is concluded that the hot homogenization and ultrasound dispersion method, isa useful method for the successful incorporation of poorly water soluble drug ramiprilwith high entrapment efficiency. The prolonged release of the drug from the solid lipidnanoparticles suggests that the frequency of administration may be reduced. Further itmay be presumed that if the nanometer range particles are obtained, the bioavailabilitymay be increased. Hence we can conclude that solid lipid nanoparticles providecontrolled release of drug and these systems are used as drug carriers for lipophilicdrugs to enhance the bioavailability of poorly water soluble drugs through nanoparticleas a drug delivery system." @default.
- W3152256148 created "2021-04-13" @default.
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- W3152256148 date "2010-03-01" @default.
- W3152256148 modified "2023-09-26" @default.
- W3152256148 title "Formulation and Evaluation of PH Triggered In Situ Gelling System of Levofloxacin" @default.
- W3152256148 hasPublicationYear "2010" @default.
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