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- W3152258656 endingPage "732" @default.
- W3152258656 startingPage "732" @default.
- W3152258656 abstract "Bile salt hydrolase (BSH) and penicillin V acylase (PVA) are related enzymes that are classified as choloylglycine hydrolases (CGH). BSH enzymes have attracted significant interest for their ability to modulate the composition of the bile acid pool, alter bile acid signaling events mediated by the host bile acid receptors FXR and TGR5 and influence cholesterol homeostasis in the host, while PVA enzymes have been widely utilised in an industrial capacity in the production of semi-synthetic antibiotics. The similarities between BSH and PVA enzymes suggest common evolution of these enzymes and shared mechanisms for substrate binding and catalysis. Here, we compare BSH and PVA through analysis of the distribution, phylogeny and biochemistry of these microbial enzymes. The development of new annotation approaches based upon functional enzyme analyses and the potential implications of BSH enzymes for host health are discussed." @default.
- W3152258656 created "2021-04-13" @default.
- W3152258656 creator A5003508542 @default.
- W3152258656 creator A5068868147 @default.
- W3152258656 creator A5072816476 @default.
- W3152258656 date "2021-03-31" @default.
- W3152258656 modified "2023-10-01" @default.
- W3152258656 title "Functional and Phylogenetic Diversity of BSH and PVA Enzymes" @default.
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- W3152258656 doi "https://doi.org/10.3390/microorganisms9040732" @default.