FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3152265807> ?p ?o ?g. }

• W3152265807 abstract "We showed previously that antioxidant enzyme heme oxygenase 1 (HO-1) is critical for Leishmania survival in visceral leishmaniasis. HO-1 inhibits host oxidative burst and inflammatory cytokine production, leading to parasite persistence. In the present study, screening of reported HO-1 transcription factors revealed that infection upregulated (4.1-fold compared to control [P < 0.001]) nuclear factor erythroid 2 (NFE2)-related factor 2 (NRF2). Silencing of NRF2 reduced both HO-1 expression and parasite survival. Investigation revealed that infection-induced transient reactive oxygen species (ROS) production dissociated NRF2 from its inhibitor KEAP1 and enabled phosphorylation-dependent nuclear translocation. Both NRF2 and HO-1 silencing in infection increased production of proinflammatory cytokines. But the level was greater in NRF2-silenced cells than in HO-1-silenced ones, suggesting the presence of other targets of NRF2. Another stress responsive transcription factor ATF3 is also induced (4.6-fold compared to control [P < 0.001]) by NRF2 during infection. Silencing of ATF3 reduced parasite survival (59.3% decrease compared to control [P < 0.001]) and increased proinflammatory cytokines. Infection-induced ATF3 recruited HDAC1 into the promoter sites of tumor necrosis factor alpha (TNF-α) and interleukin 12b (IL-12b) genes. Resulting deacetylated histones prevented NF-κB promoter binding, thereby reducing transcription of inflammatory cytokines. Administering the NRF2 inhibitor trigonelline hydrochloride to infected BALB/c mice resulted in reduced HO-1 and ATF3 expression, decreased spleen and liver parasite burdens, and increased proinflammatory cytokine levels. These results suggest that Leishmania upregulates NRF2 to activate both HO-1 and ATF3 for disease progression." @default.
• W3152265807 created "2021-04-13" @default.
• W3152265807 creator A5013627533 @default.
• W3152265807 creator A5021132901 @default.
• W3152265807 creator A5034212708 @default.
• W3152265807 creator A5058859815 @default.
• W3152265807 creator A5090802552 @default.
• W3152265807 date "2021-06-16" @default.
• W3152265807 modified "2023-10-14" @default.
• W3152265807 title "Leishmania donovani Targets Host Transcription Factor NRF2 To Activate Antioxidant Enzyme HO-1 and Transcriptional Repressor ATF3 for Establishing Infection" @default.
• W3152265807 cites W1674844815 @default.
• W3152265807 cites W1741332071 @default.
• W3152265807 cites W1873396431 @default.
• W3152265807 cites W1925193485 @default.
• W3152265807 cites W1966590237 @default.
• W3152265807 cites W1977334935 @default.
• W3152265807 cites W2048792427 @default.
• W3152265807 cites W2050512725 @default.
• W3152265807 cites W2075277951 @default.
• W3152265807 cites W2080671121 @default.
• W3152265807 cites W2084063309 @default.
• W3152265807 cites W2092328174 @default.
• W3152265807 cites W2102235987 @default.
• W3152265807 cites W2104325550 @default.
• W3152265807 cites W2104578747 @default.
• W3152265807 cites W2117444375 @default.
• W3152265807 cites W2123986306 @default.
• W3152265807 cites W2145812375 @default.
• W3152265807 cites W2158748750 @default.
• W3152265807 cites W2159820690 @default.
• W3152265807 cites W2162392154 @default.
• W3152265807 cites W2163087359 @default.
• W3152265807 cites W2164453551 @default.
• W3152265807 cites W2164663225 @default.
• W3152265807 cites W2166830657 @default.
• W3152265807 cites W2168395641 @default.
• W3152265807 cites W2169161738 @default.
• W3152265807 cites W2266696487 @default.
• W3152265807 cites W2324393681 @default.
• W3152265807 cites W2336328518 @default.
• W3152265807 cites W2340338776 @default.
• W3152265807 cites W2410012364 @default.
• W3152265807 cites W2521642386 @default.
• W3152265807 cites W2560601914 @default.
• W3152265807 cites W2611004874 @default.
• W3152265807 cites W2752005712 @default.
• W3152265807 cites W2753995352 @default.
• W3152265807 cites W2907823975 @default.
• W3152265807 cites W2954326961 @default.
• W3152265807 cites W2998859862 @default.
• W3152265807 cites W3008564638 @default.
• W3152265807 doi "https://doi.org/10.1128/iai.00764-20" @default.
• W3152265807 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/8373246" @default.
• W3152265807 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/33820818" @default.
• W3152265807 hasPublicationYear "2021" @default.
• W3152265807 type Work @default.
• W3152265807 sameAs 3152265807 @default.
• W3152265807 citedByCount "5" @default.
• W3152265807 countsByYear W31522658072022 @default.
• W3152265807 countsByYear W31522658072023 @default.
• W3152265807 crossrefType "journal-article" @default.
• W3152265807 hasAuthorship W3152265807A5013627533 @default.
• W3152265807 hasAuthorship W3152265807A5021132901 @default.
• W3152265807 hasAuthorship W3152265807A5034212708 @default.
• W3152265807 hasAuthorship W3152265807A5058859815 @default.
• W3152265807 hasAuthorship W3152265807A5090802552 @default.
• W3152265807 hasBestOaLocation W31522658072 @default.
• W3152265807 hasConcept C104317684 @default.
• W3152265807 hasConcept C119056186 @default.
• W3152265807 hasConcept C153911025 @default.
• W3152265807 hasConcept C164027704 @default.
• W3152265807 hasConcept C17991360 @default.
• W3152265807 hasConcept C203014093 @default.
• W3152265807 hasConcept C2776151105 @default.
• W3152265807 hasConcept C2776555147 @default.
• W3152265807 hasConcept C2776914184 @default.
• W3152265807 hasConcept C2778689377 @default.
• W3152265807 hasConcept C2781333301 @default.
• W3152265807 hasConcept C55493867 @default.
• W3152265807 hasConcept C77179829 @default.
• W3152265807 hasConcept C86339819 @default.
• W3152265807 hasConcept C86803240 @default.
• W3152265807 hasConceptScore W3152265807C104317684 @default.
• W3152265807 hasConceptScore W3152265807C119056186 @default.
• W3152265807 hasConceptScore W3152265807C153911025 @default.
• W3152265807 hasConceptScore W3152265807C164027704 @default.
• W3152265807 hasConceptScore W3152265807C17991360 @default.
• W3152265807 hasConceptScore W3152265807C203014093 @default.
• W3152265807 hasConceptScore W3152265807C2776151105 @default.
• W3152265807 hasConceptScore W3152265807C2776555147 @default.
• W3152265807 hasConceptScore W3152265807C2776914184 @default.
• W3152265807 hasConceptScore W3152265807C2778689377 @default.
• W3152265807 hasConceptScore W3152265807C2781333301 @default.
• W3152265807 hasConceptScore W3152265807C55493867 @default.
• W3152265807 hasConceptScore W3152265807C77179829 @default.
• W3152265807 hasConceptScore W3152265807C86339819 @default.
• W3152265807 hasConceptScore W3152265807C86803240 @default.
• W3152265807 hasFunder F4320320717 @default.
• W3152265807 hasFunder F4320320719 @default.
• W3152265807 hasFunder F4320320767 @default.

• next