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- W315236421 abstract "The actions of delta-9-THC (2.4 mg/kg) on the social behavior of rhesus and fascicularis macaque monkeys were studied following daily oral administration for periods up to several years. With the treatment schedule and dosage employed, sedative effects (reduced social interaction, relaxed postures, reduced general activity, ptosis) predominated for the first 2-3 months; a few animals intermittently exhibited a form of behavioral activation with increased pacing and other repetitive stereotyped behavioral patterns. With the treatment schedule held constant, tolerance to these behavioral effects was apparent thereafter. As these acute effects diminished, irritability and aggressiveness in treated animals increased significantly, this behavioral change was apparently not a withdrawal effect. At this stage, previously lower-ranked animals began to rise in the dominance hierarchy; overt aggression increased in treated animals and submissive behavior increased in non-treated cagemates. Under high stress condition (adjustment to new social groupings), previously lower-ranked THC-treated animals initiated overt fighting episodes leading to elevated stress hormone levels in undrugged cagemates and injuries. These observations indicated that repeated exposure to moderate amounts of THC over long periods resulted in a biologically serious impairment in the ability to exhibit appropriately adaptive behavior. This impairment apparently represented a shift in baseline behavioral characteristics rather than the effects of acute intoxication or withdrawal." @default.
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- W315236421 date "1979-01-01" @default.
- W315236421 modified "2023-10-01" @default.
- W315236421 title "SOCIAL BEHAVIOR OF RHESUS MONKEYS CHRONICALLY EXPOSED TO MODERATE AMOUNTS OF DELTA-9-TETRAHYDROCANNABINOL" @default.
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- W315236421 doi "https://doi.org/10.1016/b978-0-08-023759-6.50057-3" @default.
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