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• W3152364683 abstract "Chronic low-grade inflammation in type 2 diabetes mellitus (DM) can elicit changes in whole-body zinc metabolism. The interaction among the expression of inflammatory cytokines, zinc transporter and metallothio- nein (MT) genes in peripheral blood mononuclear cells in type 2 DM remains unclear. In a 12-week randomized controlled trial, the effects of zinc (40 mg/day) supple- mentation on the gene expression of cytokines, zinc transporters and MT in women with type 2 DM were examined. In the zinc-supplemented group, gene expres- sion of tumour necrosis factor (TNF)-a tended to be upregulated by 27 ± 10 % at week 12 compared to base- line (P = 0.053). TNF-a fold change in the zinc-treated group was higher than in those without zinc supplemen- tation (P 0.05). No significant changes were observed in the expression or fold change of interleukin (IL)-1b or IL-6. Numerous bivariate relationships were observed between the fold changes of cytokines and zinc transporters, including ZnT7 with IL-1b (P 0.01), IL-6 (P 0.01) and TNF-a (P 0.01). In multiple regression analysis, IL-1b expression was predicted by the expression of all zinc transporters and MT measured at baseline (r 2 = 0.495, P 0.05) and at week 12 (r 2 = 0.532, P 0.03). The current study presents preliminary evidence that zinc sup- plementation increases cytokine gene expression in type 2 DM. The relationships found among zinc transporters, MT and cytokines suggest close interactions between zinc homeostasis and inflammation." @default.
• W3152364683 created "2021-04-13" @default.
• W3152364683 creator A5009837897 @default.
• W3152364683 date "2015-01-01" @default.
• W3152364683 modified "2023-09-24" @default.
• W3152364683 title "TNF-a gene expression is increased following zinc supplementation in type 2 diabetes mellitus" @default.
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• W3152364683 hasPublicationYear "2015" @default.
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