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• W3152393734 abstract "Eplerenone (EPL) is a selective mineralocorticoid receptor antagonist used for treatment of chronic central serous chorioretinopathy which characterized by accumulation of subretinal fluid causing a localized area of retinal detachment. unfortunately, EPL suffers from poor oral bioavailability due to poor aqueous solubility in addition to high hepatic first pass metabolism.Aiming to improve its oral bioavailability, EPL-loaded nanostructured lipid carriers (NLCs) were prepared by the emulsification solvent evaporation method and in-vitro evaluated for particle size (PS), polydispersity index (PDI), zeta potential (ZP), and entrapment efficiency (EE%). A D-optimal design was used for study the effect of liquid lipid to solid lipid ratio, surfactant type and percentage on PS, PDI, EE%, and for data optimization. The optimized EPL-loaded NLCs system was further evaluated using in-vitro drug release and ex-vivo permeation studies through rabbit intestine in comparison to EPL aqueous suspension. The physicochemical properties of the drug in the optimized system were further examined using FT-IR and X-ray diffraction studies.The resultant NLCs showed small PS (100.85-346.60 nm), homogenous distribution (0.173-0.624), negatively charged particles (ZP -20.20 to -36.75 mV), in addition to EE% (34.31-70.64%). The optimized EPL-loaded NLCs system with a desirability value of 0.905 was suggested through the Design expert® software, containing liquid to solid lipid ratio (2:1) in presence of 0.43%w/v Pluronic® F127 as a surfactant. The optimized EPL-loaded NLCs system showed a PS of 134 nm and PDI of 0.31, in addition to high EE% (76 ± 6.56%w/w), and ZP (-32.37 mV). The ex-vivo permeation study showed two-fold higher drug permeation through rabbit intestine compared to that from the aqueous drug suspension after 24 h, confirming the ability of optimized EPL-loaded NLCs system as successful oral targeting delivery carrier.Our results pave the way for a new oral nanotherapeutic approach toward CSCR treatment. In-vivo study is currently under investigation." @default.
• W3152393734 created "2021-04-13" @default.
• W3152393734 creator A5015056306 @default.
• W3152393734 creator A5016063678 @default.
• W3152393734 creator A5020736911 @default.
• W3152393734 date "2021-01-01" @default.
• W3152393734 modified "2023-10-13" @default.
• W3152393734 title "Lipid-based nano-formulation platform for eplerenone oral delivery as a potential treatment of chronic central serous chorioretinopathy: <i>in-vitro</i> optimization and <i>ex-vivo</i> assessment" @default.
• W3152393734 cites W1712700849 @default.
• W3152393734 cites W1966982589 @default.
• W3152393734 cites W1968651552 @default.
• W3152393734 cites W1973551742 @default.
• W3152393734 cites W1983470373 @default.
• W3152393734 cites W1985204935 @default.
• W3152393734 cites W1989114914 @default.
• W3152393734 cites W1989492660 @default.
• W3152393734 cites W1991285135 @default.
• W3152393734 cites W1993788795 @default.
• W3152393734 cites W1995243183 @default.
• W3152393734 cites W1995424001 @default.
• W3152393734 cites W1996779957 @default.
• W3152393734 cites W2002017690 @default.
• W3152393734 cites W2005719079 @default.
• W3152393734 cites W2009658202 @default.
• W3152393734 cites W2011819473 @default.
• W3152393734 cites W2011920500 @default.
• W3152393734 cites W2019395934 @default.
• W3152393734 cites W2023978524 @default.
• W3152393734 cites W2025722135 @default.
• W3152393734 cites W2040095473 @default.
• W3152393734 cites W2040407517 @default.
• W3152393734 cites W2040685164 @default.
• W3152393734 cites W2049626483 @default.
• W3152393734 cites W2050399519 @default.
• W3152393734 cites W2055409818 @default.
• W3152393734 cites W2059291872 @default.
• W3152393734 cites W2060969120 @default.
• W3152393734 cites W2061346349 @default.
• W3152393734 cites W2062935758 @default.
• W3152393734 cites W2065290979 @default.
• W3152393734 cites W2065555356 @default.
• W3152393734 cites W2067778485 @default.
• W3152393734 cites W2072632039 @default.
• W3152393734 cites W2076068691 @default.
• W3152393734 cites W2089404718 @default.
• W3152393734 cites W2090241136 @default.
• W3152393734 cites W2093641552 @default.
• W3152393734 cites W2099258317 @default.
• W3152393734 cites W2105153063 @default.
• W3152393734 cites W2115235394 @default.
• W3152393734 cites W2118295919 @default.
• W3152393734 cites W2129342006 @default.
• W3152393734 cites W213060068 @default.
• W3152393734 cites W2138361094 @default.
• W3152393734 cites W2138944514 @default.
• W3152393734 cites W2142404968 @default.
• W3152393734 cites W2146408988 @default.
• W3152393734 cites W2146838269 @default.
• W3152393734 cites W2151175415 @default.
• W3152393734 cites W2151703860 @default.
• W3152393734 cites W2161946932 @default.
• W3152393734 cites W2239727806 @default.
• W3152393734 cites W2263666717 @default.
• W3152393734 cites W230956580 @default.
• W3152393734 cites W2313788777 @default.
• W3152393734 cites W2322833409 @default.
• W3152393734 cites W2343874791 @default.
• W3152393734 cites W2473025341 @default.
• W3152393734 cites W2485906658 @default.
• W3152393734 cites W2559777480 @default.
• W3152393734 cites W2605160214 @default.
• W3152393734 cites W2613052595 @default.
• W3152393734 cites W2626712725 @default.
• W3152393734 cites W2753121666 @default.
• W3152393734 cites W2770901758 @default.
• W3152393734 cites W2791029075 @default.
• W3152393734 cites W2791874270 @default.
• W3152393734 cites W2793496437 @default.
• W3152393734 cites W2810248278 @default.
• W3152393734 cites W2886302531 @default.
• W3152393734 cites W2898146268 @default.
• W3152393734 cites W2910747064 @default.
• W3152393734 cites W2924237595 @default.
• W3152393734 cites W2997068572 @default.
• W3152393734 cites W3036495350 @default.
• W3152393734 cites W4242194824 @default.
• W3152393734 cites W1997140422 @default.
• W3152393734 doi "https://doi.org/10.1080/10717544.2021.1902023" @default.
• W3152393734 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/8023249" @default.
• W3152393734 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/33787445" @default.
• W3152393734 hasPublicationYear "2021" @default.
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