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- W3152404148 abstract "The objective of the study was to evaluate the expression of matrix metalloproteinase-14 (MMP-14) in cervical carcinoma and correlate its expression with clini- copathological parameters, recurrence, and survival of the patients. The expressions of MMP-14 in normal cervical mucosa and cervical carcinoma tissue were detected with immunohistochemistry. Survival analysis by the Kaplan- Meier method was performed to assess prognostic signifi- cance. The positive expression rate of MMP-14 in cervical carcinoma tissue was 81.6 %(111/136), and there was significant difference on their positive expression rates between in cervical carcinoma tissue and in normal cer- vical mucosa(22.4 %)(13/58)(P 0.05);The positive expression rates of MMP-14 in patients with poor histo- logic differentiation, lymph node metastasis, and recur- rence group were heightened. Using Kaplan-Meier analysis, a comparison of survival curves of low versus high expressions of MMP-14 revealed a highly significant difference in human cervical carcinoma tissue (P 0.05), which suggests that overexpression of MMP-14 is associ- ated with a worse prognosis. The MMP-14 which promotes angiogenes is associated with lymph node metastasis, vascular invasion, and poor prognosis of cervical carci- noma. The current study shows that MMP-14 may be an independent prognostic factor for cervical carcinoma patients." @default.
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- W3152404148 date "2014-01-01" @default.
- W3152404148 modified "2023-09-26" @default.
- W3152404148 title "Matrix Metalloproteinase-14 Expression and Its Prognostic Value in Cervical Carcinoma" @default.
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