Matches in SemOpenAlex for { <https://semopenalex.org/work/W3152432089> ?p ?o ?g. }
Showing items 1 to 63 of
63
with 100 items per page.
- W3152432089 abstract "Aim:To determine whether cysteinyl leukotriene receptor 1(CysLT_1 receptor)is involved in N-methyl-D-aspartate(NMDA)-induced excitotoxic injury in the mouse brain.Methods:Brain injury was induced by NMDA microinjection(50-150 nmol in 0.5 μL)into the cerebral cortex.The changes in CysLT_1 receptor expression 24 h after NMDA injection and the effects of a CysLT_1 receptor antagonist, pranlukast(0.01 and 0.1 mg/kg),an NMDA receptor antagonist,ketamine(30 mg/kg),and an antioxidant,edaravone(9 mg/kg)were observed.Results:In the NMDA-injured brain,the CysLT_1 receptor mRNA,and protein expression were upregulated,and the receptor was mainly localized in the neurons and not in the astrocytes.Pranlukast,ketamine and edaravone decreased NMDA-induced injury; pranlukast(0.1 mg/kg)and ketamine inhibited the upregulated expression of the CysLT_1 receptor.Conclusion:CysLT_1 receptor expression in neurons is upregulated after NMDA injection,and NMDA-induced responses are inhibited by CysLT_1 receptor antagonists,indicating that the increased CysLT_1 receptor is involved in NMDA excitotoxicity." @default.
- W3152432089 created "2021-04-13" @default.
- W3152432089 creator A5045944029 @default.
- W3152432089 date "2006-01-01" @default.
- W3152432089 modified "2023-09-23" @default.
- W3152432089 title "Cysteinyl leukotriene receptor 1 is involved in N-methyl-D-aspartate-mediated neuronal injury in mice" @default.
- W3152432089 hasPublicationYear "2006" @default.
- W3152432089 type Work @default.
- W3152432089 sameAs 3152432089 @default.
- W3152432089 citedByCount "0" @default.
- W3152432089 crossrefType "journal-article" @default.
- W3152432089 hasAuthorship W3152432089A5045944029 @default.
- W3152432089 hasConcept C104317684 @default.
- W3152432089 hasConcept C127561419 @default.
- W3152432089 hasConcept C170493617 @default.
- W3152432089 hasConcept C185592680 @default.
- W3152432089 hasConcept C25498285 @default.
- W3152432089 hasConcept C2776885963 @default.
- W3152432089 hasConcept C2778122271 @default.
- W3152432089 hasConcept C2781012912 @default.
- W3152432089 hasConcept C55493867 @default.
- W3152432089 hasConcept C61174792 @default.
- W3152432089 hasConcept C67018056 @default.
- W3152432089 hasConcept C71924100 @default.
- W3152432089 hasConcept C98274493 @default.
- W3152432089 hasConceptScore W3152432089C104317684 @default.
- W3152432089 hasConceptScore W3152432089C127561419 @default.
- W3152432089 hasConceptScore W3152432089C170493617 @default.
- W3152432089 hasConceptScore W3152432089C185592680 @default.
- W3152432089 hasConceptScore W3152432089C25498285 @default.
- W3152432089 hasConceptScore W3152432089C2776885963 @default.
- W3152432089 hasConceptScore W3152432089C2778122271 @default.
- W3152432089 hasConceptScore W3152432089C2781012912 @default.
- W3152432089 hasConceptScore W3152432089C55493867 @default.
- W3152432089 hasConceptScore W3152432089C61174792 @default.
- W3152432089 hasConceptScore W3152432089C67018056 @default.
- W3152432089 hasConceptScore W3152432089C71924100 @default.
- W3152432089 hasConceptScore W3152432089C98274493 @default.
- W3152432089 hasOpenAccess W3152432089 @default.
- W3152432089 hasRelatedWork W1022349336 @default.
- W3152432089 hasRelatedWork W1965194593 @default.
- W3152432089 hasRelatedWork W1965669994 @default.
- W3152432089 hasRelatedWork W1971502222 @default.
- W3152432089 hasRelatedWork W1972425876 @default.
- W3152432089 hasRelatedWork W1991978045 @default.
- W3152432089 hasRelatedWork W2000320185 @default.
- W3152432089 hasRelatedWork W2005046301 @default.
- W3152432089 hasRelatedWork W2016908800 @default.
- W3152432089 hasRelatedWork W2019434048 @default.
- W3152432089 hasRelatedWork W2052483287 @default.
- W3152432089 hasRelatedWork W2103336557 @default.
- W3152432089 hasRelatedWork W2122245043 @default.
- W3152432089 hasRelatedWork W2151178348 @default.
- W3152432089 hasRelatedWork W2331237746 @default.
- W3152432089 hasRelatedWork W2417959095 @default.
- W3152432089 hasRelatedWork W2995719344 @default.
- W3152432089 hasRelatedWork W3036077775 @default.
- W3152432089 hasRelatedWork W2013417862 @default.
- W3152432089 hasRelatedWork W2231867736 @default.
- W3152432089 isParatext "false" @default.
- W3152432089 isRetracted "false" @default.
- W3152432089 magId "3152432089" @default.
- W3152432089 workType "article" @default.