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• W3152560415 abstract "Xenobiotic-mediated activation of the aryl hydrocarbon receptor (AHR) is immunotoxic in a number of immune cell types, with the B cell being a well-established sensitive target. Recent advances have provided evidence that the B cell repertoire is a heterogeneous population, with subpopulations exhibiting vastly different cellular and functional phenotypes. Recent work from our laboratory identified the T cell specific kinase lck as being differentially regulated by 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD), which is a potent activator of AHR. While LCK is primarily expressed in T cells, a subset of CD5 + B cells also express LCK. CD5 positivity describes a broad class of B lymphocytes termed innate-like B cells (ILBs) that are critical mediators of innate immunity through constitutive secretion of polyvalent natural immunoglobulin M (IgM). We hypothesized that CD5 + ILBs may be sensitive to AHR-mediated immunotoxicity. Indeed, when CD5 + B cells were isolated from the CD19 + pool and treated with TCDD, they showed increased suppression of the CD40 ligand-induced IgM response compared to CD5 - B cells. Further, characterization of the CD5 + population indicated increased basal expression of AHR , AHR repressor ( AHRR ), and cytochrome p450 family 1 member a1 ( CYP1A1 ). Indeed the levels of AHR-mediated suppression of the IgM response from individual donors strongly correlated with the percentage of the B cell pool that was CD5 + , suggesting that CD5 + B cells are more sensitive to AHR-mediated impairment. Together these data highlight the sensitive nature of CD5 + ILBs to AHR activation and provide insight into mechanisms associated with AHR activation in human B cells." @default.
• W3152560415 created "2021-04-26" @default.
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• W3152560415 date "2021-04-15" @default.
• W3152560415 modified "2023-09-24" @default.
• W3152560415 title "Identification of a Sensitive Human Immunological Target of Aryl Hydrocarbon Receptor Activation: CD5+ Innate-Like B Cells" @default.
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• W3152560415 doi "https://doi.org/10.3389/fimmu.2021.635748" @default.
• W3152560415 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/8082145" @default.
• W3152560415 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/33936048" @default.
• W3152560415 hasPublicationYear "2021" @default.
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