FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3152607480> ?p ?o ?g. }

• W3152607480 endingPage "1467" @default.
• W3152607480 startingPage "1457" @default.
• W3152607480 abstract "To investigate cross-ancestry genetics of complex traits, we conducted a phenome-wide analysis of loci with heterogeneous effects across African, Admixed-American, Central/South Asian, East Asian, European and Middle Eastern participants of the UK Biobank (N = 441 331). Testing 843 phenotypes, we identified 82 independent genomic regions mapping variants showing genome-wide significant (GWS) associations (P < 5 × 10-8) in the trans-ancestry meta-analysis and GWS heterogeneity among the ancestry-specific effects. These included (i) loci with GWS association in one ancestry and concordant but heterogeneous effects among the other ancestries and (ii) loci with a GWS association in one ancestry group and an experiment-wide significant discordant effect (P < 6.1 × 10-4) in at least another ancestry. Since the trans-ancestry GWS associations were mostly driven by the European ancestry sample size, we investigated the differences of the allele frequency (ΔAF) and linkage disequilibrium regulome tagging (ΔLD) between European populations and the other ancestries. Within loci with concordant effects, the degree of heterogeneity was associated with European-Middle Eastern ΔAF (P = 9.04 × 10-6) and ΔLD of European populations with respect to African, Admixed-American and Central/South Asian groups (P = 8.21 × 10-4, P = 7.17 × 10-4 and P = 2.16 × 10-3, respectively). Within loci with discordant effects, ΔAF and ΔLD of European populations with respect to African and Central/South Asian ancestries were associated with the degree of heterogeneity (ΔAF: P = 7.69 × 10-3 and P = 5.31 × 10-3, ΔLD: P = 0.016 and P = 2.65 × 10-4, respectively). Considering the traits associated with cross-ancestry heterogeneous loci, we observed enrichments for blood biomarkers (P = 5.7 × 10-35) and physical appearance (P = 1.38 × 10-4). This suggests that these specific phenotypic classes may present considerable cross-ancestry heterogeneity owing to large allele frequency and LD variation among worldwide populations." @default.
• W3152607480 created "2021-04-26" @default.
• W3152607480 creator A5002891044 @default.
• W3152607480 creator A5010617281 @default.
• W3152607480 creator A5041021046 @default.
• W3152607480 creator A5052727878 @default.
• W3152607480 creator A5053756905 @default.
• W3152607480 creator A5072763583 @default.
• W3152607480 creator A5079061122 @default.
• W3152607480 date "2021-04-22" @default.
• W3152607480 modified "2023-10-14" @default.
• W3152607480 title "Cross-ancestry genome-wide association studies identified heterogeneous loci associated with differences of allele frequency and regulome tagging between participants of European descent and other ancestry groups from the UK Biobank" @default.
• W3152607480 cites W1911952697 @default.
• W3152607480 cites W1915722928 @default.
• W3152607480 cites W2006189274 @default.
• W3152607480 cites W2009494639 @default.
• W3152607480 cites W2025253353 @default.
• W3152607480 cites W2037336322 @default.
• W3152607480 cites W2082704080 @default.
• W3152607480 cites W2102521965 @default.
• W3152607480 cites W2102714321 @default.
• W3152607480 cites W2104549677 @default.
• W3152607480 cites W2104797721 @default.
• W3152607480 cites W2131803107 @default.
• W3152607480 cites W2139162658 @default.
• W3152607480 cites W2141820415 @default.
• W3152607480 cites W2152061115 @default.
• W3152607480 cites W2156643192 @default.
• W3152607480 cites W2162426271 @default.
• W3152607480 cites W2166320441 @default.
• W3152607480 cites W2265603825 @default.
• W3152607480 cites W2292592996 @default.
• W3152607480 cites W2341084900 @default.
• W3152607480 cites W2489911374 @default.
• W3152607480 cites W2560111513 @default.
• W3152607480 cites W2583272461 @default.
• W3152607480 cites W2598022332 @default.
• W3152607480 cites W2603466146 @default.
• W3152607480 cites W2609984900 @default.
• W3152607480 cites W2619571184 @default.
• W3152607480 cites W2725988230 @default.
• W3152607480 cites W2756125767 @default.
• W3152607480 cites W2764014645 @default.
• W3152607480 cites W2783602503 @default.
• W3152607480 cites W2784045407 @default.
• W3152607480 cites W2805983714 @default.
• W3152607480 cites W2883415719 @default.
• W3152607480 cites W2883573930 @default.
• W3152607480 cites W2895366584 @default.
• W3152607480 cites W2895486342 @default.
• W3152607480 cites W2901303766 @default.
• W3152607480 cites W2906702113 @default.
• W3152607480 cites W2909486692 @default.
• W3152607480 cites W2910645688 @default.
• W3152607480 cites W2922534626 @default.
• W3152607480 cites W2922963777 @default.
• W3152607480 cites W2932671560 @default.
• W3152607480 cites W2936480486 @default.
• W3152607480 cites W2945852765 @default.
• W3152607480 cites W2948923376 @default.
• W3152607480 cites W2950099124 @default.
• W3152607480 cites W2952013316 @default.
• W3152607480 cites W2963160524 @default.
• W3152607480 cites W2964961432 @default.
• W3152607480 cites W2972924145 @default.
• W3152607480 cites W2973420903 @default.
• W3152607480 cites W3004083863 @default.
• W3152607480 cites W3006646039 @default.
• W3152607480 cites W3006940702 @default.
• W3152607480 cites W3037488002 @default.
• W3152607480 cites W3082575318 @default.
• W3152607480 cites W3087064672 @default.
• W3152607480 cites W3087920238 @default.
• W3152607480 cites W3088622401 @default.
• W3152607480 cites W3089324636 @default.
• W3152607480 cites W3090627945 @default.
• W3152607480 cites W3092916076 @default.
• W3152607480 cites W3109891594 @default.
• W3152607480 cites W3125359194 @default.
• W3152607480 cites W3127498788 @default.
• W3152607480 cites W3129064443 @default.
• W3152607480 cites W4230063602 @default.
• W3152607480 doi "https://doi.org/10.1093/hmg/ddab114" @default.
• W3152607480 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/8283210" @default.
• W3152607480 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/33890984" @default.
• W3152607480 hasPublicationYear "2021" @default.
• W3152607480 type Work @default.
• W3152607480 sameAs 3152607480 @default.
• W3152607480 citedByCount "4" @default.
• W3152607480 countsByYear W31526074802022 @default.
• W3152607480 countsByYear W31526074802023 @default.
• W3152607480 crossrefType "journal-article" @default.
• W3152607480 hasAuthorship W3152607480A5002891044 @default.
• W3152607480 hasAuthorship W3152607480A5010617281 @default.
• W3152607480 hasAuthorship W3152607480A5041021046 @default.
• W3152607480 hasAuthorship W3152607480A5052727878 @default.
• W3152607480 hasAuthorship W3152607480A5053756905 @default.
• W3152607480 hasAuthorship W3152607480A5072763583 @default.

• next