Matches in SemOpenAlex for { <https://semopenalex.org/work/W3152632185> ?p ?o ?g. }
Showing items 1 to 92 of
92
with 100 items per page.
- W3152632185 endingPage "368" @default.
- W3152632185 startingPage "357" @default.
- W3152632185 abstract "Ferulic acid (FA), an active component extracted from Chinese medicine, shows excellent anti-inflammatory properties and favorable safety in various animal models. However, the application of FA as an anti-inflammatory drug is hindered by its instability and short half-life in vivo . In this paper, we synthesize PEGylated diphenylalanine nanoparticles by using glutaraldehyde (GTA) as a cross-linker of diphenylalanine NH 2 -Phe–Phe-COOH and poly(ethylene glycol) methyl ether amine (PEG 5k -NH 2 ). The PEGylated Phe–Phe nanoparticles are used to deliver FA for the treatment of Rheumatoid arthritis (RA). We find that the FA-loaded PEGylated Phe–Phe nanoparticles are biocompatible and inhibit the production of reactive oxygen species (ROS) from cells effectively. After being intravenously administrated in vivo , the FA-loaded PEGylated Phe–Phe nanoparticles show prolonged circulation time and accumulate in arthritic joints. More importantly, we show that the pre-arthritis treatment with the FA-loaded PEGylated Phe–Phe nanoparticles can significantly block the progression of RA." @default.
- W3152632185 created "2021-04-26" @default.
- W3152632185 creator A5003786034 @default.
- W3152632185 creator A5012379646 @default.
- W3152632185 creator A5024818901 @default.
- W3152632185 creator A5037896778 @default.
- W3152632185 creator A5040967667 @default.
- W3152632185 creator A5064092598 @default.
- W3152632185 creator A5065243448 @default.
- W3152632185 creator A5065337906 @default.
- W3152632185 date "2021-03-01" @default.
- W3152632185 modified "2023-09-26" @default.
- W3152632185 title "Delivery of Ferulic Acid with PEGylated DiphenylalanineBased Nanoparticles for the Treatment of Arthritis in Early Stage" @default.
- W3152632185 doi "https://doi.org/10.1166/jbn.2021.3022" @default.
- W3152632185 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/33875071" @default.
- W3152632185 hasPublicationYear "2021" @default.
- W3152632185 type Work @default.
- W3152632185 sameAs 3152632185 @default.
- W3152632185 citedByCount "1" @default.
- W3152632185 countsByYear W31526321852023 @default.
- W3152632185 crossrefType "journal-article" @default.
- W3152632185 hasAuthorship W3152632185A5003786034 @default.
- W3152632185 hasAuthorship W3152632185A5012379646 @default.
- W3152632185 hasAuthorship W3152632185A5024818901 @default.
- W3152632185 hasAuthorship W3152632185A5037896778 @default.
- W3152632185 hasAuthorship W3152632185A5040967667 @default.
- W3152632185 hasAuthorship W3152632185A5064092598 @default.
- W3152632185 hasAuthorship W3152632185A5065243448 @default.
- W3152632185 hasAuthorship W3152632185A5065337906 @default.
- W3152632185 hasConcept C10138342 @default.
- W3152632185 hasConcept C13965031 @default.
- W3152632185 hasConcept C150903083 @default.
- W3152632185 hasConcept C155672457 @default.
- W3152632185 hasConcept C162324750 @default.
- W3152632185 hasConcept C171250308 @default.
- W3152632185 hasConcept C178790620 @default.
- W3152632185 hasConcept C185592680 @default.
- W3152632185 hasConcept C192562407 @default.
- W3152632185 hasConcept C203014093 @default.
- W3152632185 hasConcept C207001950 @default.
- W3152632185 hasConcept C2776964284 @default.
- W3152632185 hasConcept C2777077863 @default.
- W3152632185 hasConcept C2777516009 @default.
- W3152632185 hasConcept C2779149719 @default.
- W3152632185 hasConcept C2780213334 @default.
- W3152632185 hasConcept C54400483 @default.
- W3152632185 hasConcept C55493867 @default.
- W3152632185 hasConcept C71924100 @default.
- W3152632185 hasConcept C86803240 @default.
- W3152632185 hasConcept C98274493 @default.
- W3152632185 hasConceptScore W3152632185C10138342 @default.
- W3152632185 hasConceptScore W3152632185C13965031 @default.
- W3152632185 hasConceptScore W3152632185C150903083 @default.
- W3152632185 hasConceptScore W3152632185C155672457 @default.
- W3152632185 hasConceptScore W3152632185C162324750 @default.
- W3152632185 hasConceptScore W3152632185C171250308 @default.
- W3152632185 hasConceptScore W3152632185C178790620 @default.
- W3152632185 hasConceptScore W3152632185C185592680 @default.
- W3152632185 hasConceptScore W3152632185C192562407 @default.
- W3152632185 hasConceptScore W3152632185C203014093 @default.
- W3152632185 hasConceptScore W3152632185C207001950 @default.
- W3152632185 hasConceptScore W3152632185C2776964284 @default.
- W3152632185 hasConceptScore W3152632185C2777077863 @default.
- W3152632185 hasConceptScore W3152632185C2777516009 @default.
- W3152632185 hasConceptScore W3152632185C2779149719 @default.
- W3152632185 hasConceptScore W3152632185C2780213334 @default.
- W3152632185 hasConceptScore W3152632185C54400483 @default.
- W3152632185 hasConceptScore W3152632185C55493867 @default.
- W3152632185 hasConceptScore W3152632185C71924100 @default.
- W3152632185 hasConceptScore W3152632185C86803240 @default.
- W3152632185 hasConceptScore W3152632185C98274493 @default.
- W3152632185 hasIssue "3" @default.
- W3152632185 hasLocation W31526321851 @default.
- W3152632185 hasOpenAccess W3152632185 @default.
- W3152632185 hasPrimaryLocation W31526321851 @default.
- W3152632185 hasRelatedWork W1994112378 @default.
- W3152632185 hasRelatedWork W2008369019 @default.
- W3152632185 hasRelatedWork W2016780456 @default.
- W3152632185 hasRelatedWork W2031680035 @default.
- W3152632185 hasRelatedWork W2052829077 @default.
- W3152632185 hasRelatedWork W2053660806 @default.
- W3152632185 hasRelatedWork W2113502101 @default.
- W3152632185 hasRelatedWork W2585268074 @default.
- W3152632185 hasRelatedWork W2775566911 @default.
- W3152632185 hasRelatedWork W2885704097 @default.
- W3152632185 hasVolume "17" @default.
- W3152632185 isParatext "false" @default.
- W3152632185 isRetracted "false" @default.
- W3152632185 magId "3152632185" @default.
- W3152632185 workType "article" @default.