Matches in SemOpenAlex for { <https://semopenalex.org/work/W3152728916> ?p ?o ?g. }
- W3152728916 endingPage "111484" @default.
- W3152728916 startingPage "111484" @default.
- W3152728916 abstract "The inhibition of glycosidase activity is regarded as an effective treatment for diabetes mellitus. Bilberry (Vaccinium myrtillus L.) fruit has a high content of anthocyanins with various biological activities. The objective of this study was to investigate the inhibitory activity of anthocyanin-rich bilberry extract (BE) on α-glucosidase and α-amylase and their interaction mechanisms in vitro. The IC50 values of BE with regard to α-glucosidase and α-amylase inhibition were 0.31 ± 0.02 and 4.06 ± 0.12 mg/mL, respectively. The enzyme kinetics revealed that BE acts as a mixed-type inhibitor against α-glucosidase and α-amylase. Moreover, the fluorescence of two glucosidases showed significant quenching by BE. FTIR spectra and differential scanning calorimetry (DSC) indicated that BE changed the enzyme structure and decreased its stability. A morphological observation of starch granules found that BE inhibited the activity of α-amylase to postpone the hydrolysis of starch. Furthermore, the in vivo study further showed that BE had a hypoglycaemic effect. The most suitable conformation (main anthocyanidins of BE) and optimal binding site (α-glucosidase, α-amylase) were assayed by molecular docking. In conclusion, this study revealed that BE could be a potential glycosidase inhibitor." @default.
- W3152728916 created "2021-04-26" @default.
- W3152728916 creator A5000893456 @default.
- W3152728916 creator A5008701844 @default.
- W3152728916 creator A5010721128 @default.
- W3152728916 creator A5029938413 @default.
- W3152728916 creator A5035904696 @default.
- W3152728916 creator A5062183746 @default.
- W3152728916 creator A5077841709 @default.
- W3152728916 creator A5083155217 @default.
- W3152728916 creator A5085380069 @default.
- W3152728916 date "2021-06-01" @default.
- W3152728916 modified "2023-10-01" @default.
- W3152728916 title "In vitro and in vivo inhibitory effect of anthocyanin-rich bilberry extract on α-glucosidase and α-amylase" @default.
- W3152728916 cites W1483954977 @default.
- W3152728916 cites W1886849294 @default.
- W3152728916 cites W1968373028 @default.
- W3152728916 cites W1973537232 @default.
- W3152728916 cites W1988203022 @default.
- W3152728916 cites W1998251376 @default.
- W3152728916 cites W2006634844 @default.
- W3152728916 cites W2008531998 @default.
- W3152728916 cites W2010592688 @default.
- W3152728916 cites W2022521911 @default.
- W3152728916 cites W2037939062 @default.
- W3152728916 cites W2050391293 @default.
- W3152728916 cites W2054015760 @default.
- W3152728916 cites W2058583056 @default.
- W3152728916 cites W2058658653 @default.
- W3152728916 cites W2069305394 @default.
- W3152728916 cites W2092654658 @default.
- W3152728916 cites W2105990608 @default.
- W3152728916 cites W2123076266 @default.
- W3152728916 cites W2259189936 @default.
- W3152728916 cites W2311421094 @default.
- W3152728916 cites W2317222587 @default.
- W3152728916 cites W2324810756 @default.
- W3152728916 cites W2331749739 @default.
- W3152728916 cites W2571171896 @default.
- W3152728916 cites W2626712616 @default.
- W3152728916 cites W2626780962 @default.
- W3152728916 cites W2734756734 @default.
- W3152728916 cites W2786563598 @default.
- W3152728916 cites W2803522209 @default.
- W3152728916 cites W2884372486 @default.
- W3152728916 cites W2890753413 @default.
- W3152728916 cites W2913382351 @default.
- W3152728916 cites W2917698934 @default.
- W3152728916 cites W2949780892 @default.
- W3152728916 cites W2956009301 @default.
- W3152728916 cites W2966465238 @default.
- W3152728916 cites W2972995455 @default.
- W3152728916 cites W2982053051 @default.
- W3152728916 cites W2987504319 @default.
- W3152728916 cites W2997683965 @default.
- W3152728916 cites W3002735536 @default.
- W3152728916 cites W3012440094 @default.
- W3152728916 cites W3031727020 @default.
- W3152728916 cites W3092309387 @default.
- W3152728916 doi "https://doi.org/10.1016/j.lwt.2021.111484" @default.
- W3152728916 hasPublicationYear "2021" @default.
- W3152728916 type Work @default.
- W3152728916 sameAs 3152728916 @default.
- W3152728916 citedByCount "40" @default.
- W3152728916 countsByYear W31527289162021 @default.
- W3152728916 countsByYear W31527289162022 @default.
- W3152728916 countsByYear W31527289162023 @default.
- W3152728916 crossrefType "journal-article" @default.
- W3152728916 hasAuthorship W3152728916A5000893456 @default.
- W3152728916 hasAuthorship W3152728916A5008701844 @default.
- W3152728916 hasAuthorship W3152728916A5010721128 @default.
- W3152728916 hasAuthorship W3152728916A5029938413 @default.
- W3152728916 hasAuthorship W3152728916A5035904696 @default.
- W3152728916 hasAuthorship W3152728916A5062183746 @default.
- W3152728916 hasAuthorship W3152728916A5077841709 @default.
- W3152728916 hasAuthorship W3152728916A5083155217 @default.
- W3152728916 hasAuthorship W3152728916A5085380069 @default.
- W3152728916 hasConcept C150903083 @default.
- W3152728916 hasConcept C170835558 @default.
- W3152728916 hasConcept C181199279 @default.
- W3152728916 hasConcept C185592680 @default.
- W3152728916 hasConcept C202751555 @default.
- W3152728916 hasConcept C207001950 @default.
- W3152728916 hasConcept C2775908993 @default.
- W3152728916 hasConcept C2776617576 @default.
- W3152728916 hasConcept C2776993194 @default.
- W3152728916 hasConcept C2777752497 @default.
- W3152728916 hasConcept C2778945092 @default.
- W3152728916 hasConcept C2781267450 @default.
- W3152728916 hasConcept C31903555 @default.
- W3152728916 hasConcept C529335014 @default.
- W3152728916 hasConcept C55493867 @default.
- W3152728916 hasConcept C59822182 @default.
- W3152728916 hasConcept C86803240 @default.
- W3152728916 hasConcept C94412978 @default.
- W3152728916 hasConceptScore W3152728916C150903083 @default.
- W3152728916 hasConceptScore W3152728916C170835558 @default.
- W3152728916 hasConceptScore W3152728916C181199279 @default.