FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3152755878> ?p ?o ?g. }

• W3152755878 endingPage "378" @default.
• W3152755878 startingPage "367" @default.
• W3152755878 abstract "In the brain, both HIV-1 and methamphetamine (meth) use result in increases in oxidative and nitrosative stress. This redox stress is thought to contribute to the pathogenesis of HIV-associated neurocognitive disorder (HAND) and further worsening cognitive activity in the setting of drug abuse. One consequence of such redox stress is aberrant protein S-nitrosylation, derived from nitric oxide, which may disrupt normal protein activity. Here, we report an improved, mass spectrometry-based technique to assess S-nitrosylated protein in human postmortem brains using selective enrichment of S-nitrosocysteine residues with an organomercury resin. The data show increasing S-nitrosylation of tricarboxylic acid (TCA) enzymes in the setting of HAND and HAND/meth use compared with HIV+ control brains without CNS pathology. The consequence is systematic inhibition of multiple TCA cycle enzymes, resulting in energy collapse that can contribute to the neuronal and synaptic damage observed in HAND and meth use." @default.
• W3152755878 created "2021-04-26" @default.
• W3152755878 creator A5006268085 @default.
• W3152755878 creator A5014451415 @default.
• W3152755878 creator A5055821313 @default.
• W3152755878 creator A5059684224 @default.
• W3152755878 creator A5061941293 @default.
• W3152755878 creator A5066753734 @default.
• W3152755878 creator A5066879136 @default.
• W3152755878 creator A5074186358 @default.
• W3152755878 creator A5082818546 @default.
• W3152755878 date "2021-04-19" @default.
• W3152755878 modified "2023-10-16" @default.
• W3152755878 title "TCA cycle metabolic compromise due to an aberrant S-nitrosoproteome in HIV-associated neurocognitive disorder with methamphetamine use" @default.
• W3152755878 cites W1596348596 @default.
• W3152755878 cites W1801632992 @default.
• W3152755878 cites W1965917470 @default.
• W3152755878 cites W1967646152 @default.
• W3152755878 cites W1968131336 @default.
• W3152755878 cites W1968780203 @default.
• W3152755878 cites W1981845473 @default.
• W3152755878 cites W1982536922 @default.
• W3152755878 cites W1983661921 @default.
• W3152755878 cites W1991454533 @default.
• W3152755878 cites W2001261203 @default.
• W3152755878 cites W2007314568 @default.
• W3152755878 cites W2009006904 @default.
• W3152755878 cites W2014856221 @default.
• W3152755878 cites W2016422864 @default.
• W3152755878 cites W2016927879 @default.
• W3152755878 cites W2019453676 @default.
• W3152755878 cites W2022972602 @default.
• W3152755878 cites W2024244537 @default.
• W3152755878 cites W2027641362 @default.
• W3152755878 cites W2036982001 @default.
• W3152755878 cites W2038006724 @default.
• W3152755878 cites W2038071695 @default.
• W3152755878 cites W2062384458 @default.
• W3152755878 cites W2065773243 @default.
• W3152755878 cites W2066903830 @default.
• W3152755878 cites W2069288489 @default.
• W3152755878 cites W2071468228 @default.
• W3152755878 cites W2087292928 @default.
• W3152755878 cites W2089074317 @default.
• W3152755878 cites W2091954160 @default.
• W3152755878 cites W2092338483 @default.
• W3152755878 cites W2118335987 @default.
• W3152755878 cites W2126788226 @default.
• W3152755878 cites W2127158554 @default.
• W3152755878 cites W2138902434 @default.
• W3152755878 cites W2153433893 @default.
• W3152755878 cites W2156107840 @default.
• W3152755878 cites W2160610690 @default.
• W3152755878 cites W2202641067 @default.
• W3152755878 cites W2255749509 @default.
• W3152755878 cites W2311894028 @default.
• W3152755878 cites W2416068580 @default.
• W3152755878 cites W2418105944 @default.
• W3152755878 cites W2483026649 @default.
• W3152755878 cites W26533597 @default.
• W3152755878 cites W2739924689 @default.
• W3152755878 cites W2766367771 @default.
• W3152755878 cites W2907315139 @default.
• W3152755878 cites W2930346360 @default.
• W3152755878 cites W2945612803 @default.
• W3152755878 cites W2980746109 @default.
• W3152755878 cites W3107464740 @default.
• W3152755878 doi "https://doi.org/10.1007/s13365-021-00970-4" @default.
• W3152755878 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/8477648" @default.
• W3152755878 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/33942273" @default.
• W3152755878 hasPublicationYear "2021" @default.
• W3152755878 type Work @default.
• W3152755878 sameAs 3152755878 @default.
• W3152755878 citedByCount "4" @default.
• W3152755878 countsByYear W31527558782021 @default.
• W3152755878 countsByYear W31527558782022 @default.
• W3152755878 countsByYear W31527558782023 @default.
• W3152755878 crossrefType "journal-article" @default.
• W3152755878 hasAuthorship W3152755878A5006268085 @default.
• W3152755878 hasAuthorship W3152755878A5014451415 @default.
• W3152755878 hasAuthorship W3152755878A5055821313 @default.
• W3152755878 hasAuthorship W3152755878A5059684224 @default.
• W3152755878 hasAuthorship W3152755878A5061941293 @default.
• W3152755878 hasAuthorship W3152755878A5066753734 @default.
• W3152755878 hasAuthorship W3152755878A5066879136 @default.
• W3152755878 hasAuthorship W3152755878A5074186358 @default.
• W3152755878 hasAuthorship W3152755878A5082818546 @default.
• W3152755878 hasBestOaLocation W31527558782 @default.
• W3152755878 hasConcept C126322002 @default.
• W3152755878 hasConcept C15744967 @default.
• W3152755878 hasConcept C165135838 @default.
• W3152755878 hasConcept C166940927 @default.
• W3152755878 hasConcept C169760540 @default.
• W3152755878 hasConcept C169900460 @default.
• W3152755878 hasConcept C172467417 @default.
• W3152755878 hasConcept C178790620 @default.
• W3152755878 hasConcept C181199279 @default.
• W3152755878 hasConcept C185592680 @default.

• next