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• W3152758858 abstract "In situ 3D printing technologies is a new frontier for highly personalized medicine, which requires suitable bioink with rheology, biocompatibility, and gelation kinetics to support the right shape and mechanical properties of the printed construct. To this end, a facile design of thermo/photo dual cure composite hydrogel was proposed using MHBC and soluble collagen in this study. M/C composite hydrogel exhibited rapid thermo-induced sol-gel transition and contraction, tunable mechanical properties, proper microstructure and biodegradability for 3D cell culture, as well as improve cyto-compatibility, all of which were dependent upon the methacrylation degree of MHBC and M/C ratios. The printability of the optimal formulation (3% MHBC/1% collagen) was validated by its mild printing condition, rapid gelation of bioink at 37 °C and simple postprocessing manipulation. Both desirable printability and cyto-compatibility enable M/C composite hydrogel a potential candidate as bioink to be applied for in situ 3D bioprinting. • The composite hydrogel was prepared by thermo/photo dual cure. • The composite hydrogel formed rapidly under room temperature by sol-gel transition. • The composite hydrogel provided RGD motif to significantly enhance cell adhesion. • The composite hydrogel exhibited desirable printability and biocompatibility. • The composite hydrogel could be a potential bioink for in situ 3D bioprinting." @default.
• W3152758858 created "2021-04-26" @default.
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• W3152758858 date "2021-07-01" @default.
• W3152758858 modified "2023-10-05" @default.
• W3152758858 title "Dual cure (thermal/photo) composite hydrogel derived from chitosan/collagen for in situ 3D bioprinting" @default.
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• W3152758858 doi "https://doi.org/10.1016/j.ijbiomac.2021.04.058" @default.
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