FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3152769894> ?p ?o ?g. }

• W3152769894 abstract "C3 glomerulopathy (C3G) is a recent disease classification that is characterized by the presence of glomerular deposits (composed of C3) in the absence of significant amounts of immunoglobulin and comprises dense deposit disease and C3 glomerulonephritis (C3GN). Most C3GN manifests as membranoproliferative, mesangial proliferative glomerulonephritis patterns via light microscopy. Pure membranous nephropathy (MN)-like glomerular lesions are rare manifestations of C3GN. Anti-neutrophil cytoplasmic antibodies (ANCAs) are also seldomly reported to be positive in C3GN. Herein, we report the case of a C3GN patient presenting with an MN-like glomerular pattern with ANCA positivity.A 68-year-old woman was admitted to a local hospital with elevated serum creatinine for two weeks. Laboratory tests showed a hemoglobin level of 85 g/L. Urinalysis was positive for 2 + protein and 360 RBCs/HPF. Blood biochemistry analysis revealed the following concentrations: albumin, 30.3 g/L; globulin, 46.2 g/L; blood urea nitrogen, 19.9 mmol/L; and serum creatinine, 234 µmol/L. The serum C3 level was 0.4950 g/L, and the serum C4 level was 0.1050 g/L. The direct Coombs test was positive. Serologic testing for ANCA revealed the presence of p-ANCA (1:10) by indirect immunofluorescence microscopy assay, as well as the presence of PR3 1.2 (normal range < 1) and MPO 3.5 (normal range < 1) by enzyme immunoassay. Renal biopsy sample pathology showed 2/6 cellular crescents and thickened glomerular basement membranes. Immunofluorescence testing revealed only diffuse, finely granular depositions of C3 along the glomerular capillary walls in frozen and paraffin-embedded tissue sections. Electron microscopy demonstrated the presence of subepithelial electron-dense deposits, similar to those that are observed in membranous nephropathy. Corticosteroid and cyclophosphamide were administered, with a subsequent improvement in renal function.We present the rare case of a patient with MN-like C3GN with ANCA positivity. C3GN with ANCA positivity may be represented by more crescents, severe renal dysfunction and more extrarenal manifestations. More cases are needed to elucidate the clinicopathologic features and optimal treatments of these patients." @default.
• W3152769894 created "2021-04-26" @default.
• W3152769894 creator A5002511558 @default.
• W3152769894 creator A5005053576 @default.
• W3152769894 creator A5072861069 @default.
• W3152769894 creator A5076805460 @default.
• W3152769894 date "2021-04-21" @default.
• W3152769894 modified "2023-10-09" @default.
• W3152769894 title "C3 glomerulonephritis associated with ANCA positivity: a case report" @default.
• W3152769894 cites W1964816580 @default.
• W3152769894 cites W1967241604 @default.
• W3152769894 cites W1970345179 @default.
• W3152769894 cites W1977818941 @default.
• W3152769894 cites W1992552556 @default.
• W3152769894 cites W1993041716 @default.
• W3152769894 cites W2056027822 @default.
• W3152769894 cites W2068278360 @default.
• W3152769894 cites W2081522308 @default.
• W3152769894 cites W2093780976 @default.
• W3152769894 cites W2107368919 @default.
• W3152769894 cites W2107516496 @default.
• W3152769894 cites W2122595921 @default.
• W3152769894 cites W2122611620 @default.
• W3152769894 cites W2141225393 @default.
• W3152769894 cites W2149476023 @default.
• W3152769894 cites W2151241196 @default.
• W3152769894 cites W2177348148 @default.
• W3152769894 cites W2269570872 @default.
• W3152769894 cites W2278498148 @default.
• W3152769894 cites W2738815790 @default.
• W3152769894 cites W2882422742 @default.
• W3152769894 cites W2890633490 @default.
• W3152769894 cites W3003351527 @default.
• W3152769894 cites W3012449870 @default.
• W3152769894 cites W3041680255 @default.
• W3152769894 cites W4233885503 @default.
• W3152769894 cites W954655434 @default.
• W3152769894 doi "https://doi.org/10.1186/s12882-021-02354-6" @default.
• W3152769894 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/8061169" @default.
• W3152769894 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/33882866" @default.
• W3152769894 hasPublicationYear "2021" @default.
• W3152769894 type Work @default.
• W3152769894 sameAs 3152769894 @default.
• W3152769894 citedByCount "1" @default.
• W3152769894 countsByYear W31527698942023 @default.
• W3152769894 crossrefType "journal-article" @default.
• W3152769894 hasAuthorship W3152769894A5002511558 @default.
• W3152769894 hasAuthorship W3152769894A5005053576 @default.
• W3152769894 hasAuthorship W3152769894A5072861069 @default.
• W3152769894 hasAuthorship W3152769894A5076805460 @default.
• W3152769894 hasBestOaLocation W31527698941 @default.
• W3152769894 hasConcept C126322002 @default.
• W3152769894 hasConcept C142724271 @default.
• W3152769894 hasConcept C2775934546 @default.
• W3152769894 hasConcept C2775998817 @default.
• W3152769894 hasConcept C2776115139 @default.
• W3152769894 hasConcept C2778176769 @default.
• W3152769894 hasConcept C2780091579 @default.
• W3152769894 hasConcept C2780199430 @default.
• W3152769894 hasConcept C2780306776 @default.
• W3152769894 hasConcept C2780368995 @default.
• W3152769894 hasConcept C2781036514 @default.
• W3152769894 hasConcept C2781087799 @default.
• W3152769894 hasConcept C54847362 @default.
• W3152769894 hasConcept C71924100 @default.
• W3152769894 hasConceptScore W3152769894C126322002 @default.
• W3152769894 hasConceptScore W3152769894C142724271 @default.
• W3152769894 hasConceptScore W3152769894C2775934546 @default.
• W3152769894 hasConceptScore W3152769894C2775998817 @default.
• W3152769894 hasConceptScore W3152769894C2776115139 @default.
• W3152769894 hasConceptScore W3152769894C2778176769 @default.
• W3152769894 hasConceptScore W3152769894C2780091579 @default.
• W3152769894 hasConceptScore W3152769894C2780199430 @default.
• W3152769894 hasConceptScore W3152769894C2780306776 @default.
• W3152769894 hasConceptScore W3152769894C2780368995 @default.
• W3152769894 hasConceptScore W3152769894C2781036514 @default.
• W3152769894 hasConceptScore W3152769894C2781087799 @default.
• W3152769894 hasConceptScore W3152769894C54847362 @default.
• W3152769894 hasConceptScore W3152769894C71924100 @default.
• W3152769894 hasIssue "1" @default.
• W3152769894 hasLocation W31527698941 @default.
• W3152769894 hasLocation W31527698942 @default.
• W3152769894 hasLocation W31527698943 @default.
• W3152769894 hasLocation W31527698944 @default.
• W3152769894 hasOpenAccess W3152769894 @default.
• W3152769894 hasPrimaryLocation W31527698941 @default.
• W3152769894 hasRelatedWork W1985579480 @default.
• W3152769894 hasRelatedWork W2014937730 @default.
• W3152769894 hasRelatedWork W2046804397 @default.
• W3152769894 hasRelatedWork W2105709129 @default.
• W3152769894 hasRelatedWork W2140084624 @default.
• W3152769894 hasRelatedWork W2297801988 @default.
• W3152769894 hasRelatedWork W2315653347 @default.
• W3152769894 hasRelatedWork W2623266453 @default.
• W3152769894 hasRelatedWork W2986615354 @default.
• W3152769894 hasRelatedWork W3152769894 @default.
• W3152769894 hasVolume "22" @default.
• W3152769894 isParatext "false" @default.
• W3152769894 isRetracted "false" @default.
• W3152769894 magId "3152769894" @default.

• next