Matches in SemOpenAlex for { <https://semopenalex.org/work/W3152809446> ?p ?o ?g. }
- W3152809446 abstract "The structural paradigm that the sequence of a protein encodes for a unique three-dimensional native fold does not acknowledge the intrinsic plasticity encapsulated in conformational free energy landscapes. Metamorphic proteins are a recently discovered class of biomolecules that illustrate this plasticity by folding into at least two distinct native state structures of comparable stability in the absence of ligands or cofactors to facilitate fold-switching. The expanding list of metamorphic proteins clearly shows that these proteins are not mere aberrations in protein evolution, but may have actually been a consequence of distinctive patterns in selection pressure such as those found in virus-host co-evolution. In this review, we describe the structure-function relationships observed in well-studied metamorphic protein systems, with specific focus on how functional residues are sequestered or exposed in the two folds of the protein. We also discuss the implications of metamorphosis for protein evolution and the efforts that are underway to predict metamorphic systems from sequence properties alone." @default.
- W3152809446 created "2021-04-26" @default.
- W3152809446 creator A5025494876 @default.
- W3152809446 creator A5050152126 @default.
- W3152809446 creator A5082131126 @default.
- W3152809446 date "2021-04-01" @default.
- W3152809446 modified "2023-09-25" @default.
- W3152809446 title "Metamorphic proteins: the Janus proteins of structural biology" @default.
- W3152809446 cites W1148878366 @default.
- W3152809446 cites W1550289833 @default.
- W3152809446 cites W1579430094 @default.
- W3152809446 cites W1826357911 @default.
- W3152809446 cites W1839642627 @default.
- W3152809446 cites W1968325951 @default.
- W3152809446 cites W1977387387 @default.
- W3152809446 cites W1979666917 @default.
- W3152809446 cites W1981159786 @default.
- W3152809446 cites W1981768599 @default.
- W3152809446 cites W1982461229 @default.
- W3152809446 cites W1983086155 @default.
- W3152809446 cites W1985854865 @default.
- W3152809446 cites W1988625445 @default.
- W3152809446 cites W1990415230 @default.
- W3152809446 cites W1993836872 @default.
- W3152809446 cites W1994922455 @default.
- W3152809446 cites W2007533476 @default.
- W3152809446 cites W2007808117 @default.
- W3152809446 cites W2013668904 @default.
- W3152809446 cites W2014918426 @default.
- W3152809446 cites W2016559844 @default.
- W3152809446 cites W2017518375 @default.
- W3152809446 cites W2018970839 @default.
- W3152809446 cites W2019607838 @default.
- W3152809446 cites W2023926109 @default.
- W3152809446 cites W2029625793 @default.
- W3152809446 cites W2032836888 @default.
- W3152809446 cites W2033416116 @default.
- W3152809446 cites W2035571475 @default.
- W3152809446 cites W2041535683 @default.
- W3152809446 cites W2044730187 @default.
- W3152809446 cites W2049888624 @default.
- W3152809446 cites W2051520506 @default.
- W3152809446 cites W2052073894 @default.
- W3152809446 cites W2052962917 @default.
- W3152809446 cites W2053304168 @default.
- W3152809446 cites W2053655346 @default.
- W3152809446 cites W2054892326 @default.
- W3152809446 cites W2056654051 @default.
- W3152809446 cites W2057334048 @default.
- W3152809446 cites W2067680762 @default.
- W3152809446 cites W2068367489 @default.
- W3152809446 cites W2069987792 @default.
- W3152809446 cites W2073390681 @default.
- W3152809446 cites W2078461833 @default.
- W3152809446 cites W2078786709 @default.
- W3152809446 cites W2079151240 @default.
- W3152809446 cites W2080871410 @default.
- W3152809446 cites W2084221077 @default.
- W3152809446 cites W2087625931 @default.
- W3152809446 cites W2090023254 @default.
- W3152809446 cites W2092203973 @default.
- W3152809446 cites W2094602426 @default.
- W3152809446 cites W2099043326 @default.
- W3152809446 cites W2099279699 @default.
- W3152809446 cites W2104475286 @default.
- W3152809446 cites W2105286275 @default.
- W3152809446 cites W2105717859 @default.
- W3152809446 cites W2106531843 @default.
- W3152809446 cites W2111429941 @default.
- W3152809446 cites W2112512547 @default.
- W3152809446 cites W2114675905 @default.
- W3152809446 cites W2117997123 @default.
- W3152809446 cites W2123356980 @default.
- W3152809446 cites W2127975742 @default.
- W3152809446 cites W2128150699 @default.
- W3152809446 cites W2129543447 @default.
- W3152809446 cites W2132094595 @default.
- W3152809446 cites W2133435867 @default.
- W3152809446 cites W2133671332 @default.
- W3152809446 cites W2136345529 @default.
- W3152809446 cites W2141816871 @default.
- W3152809446 cites W2142533333 @default.
- W3152809446 cites W2145183041 @default.
- W3152809446 cites W2150269313 @default.
- W3152809446 cites W2152144929 @default.
- W3152809446 cites W2153745204 @default.
- W3152809446 cites W2154241215 @default.
- W3152809446 cites W2161522127 @default.
- W3152809446 cites W2165581033 @default.
- W3152809446 cites W2169131251 @default.
- W3152809446 cites W2170492136 @default.
- W3152809446 cites W2174005011 @default.
- W3152809446 cites W2191960775 @default.
- W3152809446 cites W2300545781 @default.
- W3152809446 cites W2328429529 @default.
- W3152809446 cites W2329582709 @default.
- W3152809446 cites W2463388409 @default.
- W3152809446 cites W2551571126 @default.
- W3152809446 cites W2596246619 @default.
- W3152809446 cites W2597024964 @default.