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- W3152862985 endingPage "111155" @default.
- W3152862985 startingPage "111155" @default.
- W3152862985 abstract "The exposure to airborne particulate matter (PM) increases the risk of developing human diseases. Epigenetic mechanisms have been related to environmental exposures and human diseases. The present review is focused on current available studies, which show the relationship between epigenetic marks, exposure to air pollution and human's health. Air contaminants involved in epigenetic changes have been related to different specific mechanisms (DNA methylation, post-translational histone modifications and non-coding RNA transcripts), which are described in separate sections. Several studies describe how these epigenetic mechanisms are influenced by environmental factors including air pollution. This interaction between PM and epigenetic factors results in an altered profile of these marks, in both, globally and locus specific. Following this connection, specific epigenetic marks can be used as biomarkers, as well as, to find new therapeutic targets. For this purpose, some significant characteristics have been highlighted, such as, the spatiotemporal specificity of these marks, the relevance of the collected tissue and the specific changes stability. Air pollution has been related to a higher mortality rate due to non-accidental deaths. This exposure to particulate matter induces changes to the epigenome, which are increasing the susceptibility of human diseases. In conclusion, as several epigenetic change mechanisms remain unclear yet, further analyses derived from PM exposure must be performed to find new targets and disease biomarkers. • Air pollution has been related to a higher mortality rate due to non-accidental deaths. • Exposure to particulate matter induces changes to the epigenome. • Epigenetic changes increase the susceptibility of distinct human diseases. • Particulate matter derived epigenetic marks are tissue and state specific." @default.
- W3152862985 created "2021-04-26" @default.
- W3152862985 creator A5032846863 @default.
- W3152862985 creator A5050565703 @default.
- W3152862985 creator A5078677234 @default.
- W3152862985 date "2021-06-01" @default.
- W3152862985 modified "2023-09-30" @default.
- W3152862985 title "Epigenetic related changes on air quality" @default.
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- W3152862985 doi "https://doi.org/10.1016/j.envres.2021.111155" @default.
- W3152862985 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/33891958" @default.
- W3152862985 hasPublicationYear "2021" @default.
- W3152862985 type Work @default.