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• W3152958227 endingPage "287" @default.
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• W3152958227 abstract "Adenosine is a potent modulator that has a tremendous effect on the immune system. Adenosine affects T cell activity, and is necessary in maintaining the T helper/regulatory T cell (Treg ) ratio. Adenosine signalling is also involved in activating neutrophils and the formation of neutrophil extracellular traps (NETs), which has been linked to autoimmune disorders. Therefore, adenosine, through its receptors, is extremely important in maintaining homeostasis and involved in the development of autoimmune diseases. In this study, we aim to evaluate the role of adenosine A1 and A2A receptors in involvement of autoimmune diseases. We studied adenosine regulation by NETosis in vitro, and used two murine models of autoimmune diseases: type I diabetes mellitus (T1DM) induced by low-dose streptozotocin and pristane-induced systemic lupus erythematosus (SLE). We have found that A1 R enhances and A2A R suppresses NETosis. In addition, in both models, A1 R-knock-out (KO) mice were predisposed to the development of autoimmunity. In the SLE model in wild-type (WT) mice we observed a decline of A1 R mRNA levels 6 h after pristane injection that was parallel to lymphocyte reduction. Following pristane, 43% of A1 R-KO mice suffered from lupus-like disease while WT mice remained without any sign of disease at 36 weeks. In WT mice, at 10 days A2A R mRNA levels were significantly higher compared to A1R-KO mice. Similar to SLE, in the T1DM model the presence of A1 R and A2A R was protective. Our data suggest that, in autoimmune diseases, the acute elimination of lymphocytes and reduction of DNA release due to NETosis depends upon A1 R desensitization and long-term suppression of A2A R." @default.
• W3152958227 created "2021-04-26" @default.
• W3152958227 creator A5021441724 @default.
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• W3152958227 date "2021-06-02" @default.
• W3152958227 modified "2023-10-10" @default.
• W3152958227 title "A1 and A2A adenosine receptors play a protective role to reduce prevalence of autoimmunity following tissue damage" @default.
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• W3152958227 cites W1673744647 @default.
• W3152958227 cites W1705652018 @default.
• W3152958227 cites W1898549991 @default.
• W3152958227 cites W1972644534 @default.
• W3152958227 cites W1976874658 @default.
• W3152958227 cites W1990113288 @default.
• W3152958227 cites W1991133811 @default.
• W3152958227 cites W1998976439 @default.
• W3152958227 cites W2003483275 @default.
• W3152958227 cites W2023020566 @default.
• W3152958227 cites W2031462278 @default.
• W3152958227 cites W2035964694 @default.
• W3152958227 cites W2038072513 @default.
• W3152958227 cites W2040020188 @default.
• W3152958227 cites W2043281436 @default.
• W3152958227 cites W2048939079 @default.
• W3152958227 cites W2052081866 @default.
• W3152958227 cites W2062389412 @default.
• W3152958227 cites W2070743921 @default.
• W3152958227 cites W2074569502 @default.
• W3152958227 cites W2076206556 @default.
• W3152958227 cites W2080319205 @default.
• W3152958227 cites W2088012387 @default.
• W3152958227 cites W2091512988 @default.
• W3152958227 cites W2091609068 @default.
• W3152958227 cites W2105420327 @default.
• W3152958227 cites W2106190040 @default.
• W3152958227 cites W2108661128 @default.
• W3152958227 cites W2109741445 @default.
• W3152958227 cites W2113148752 @default.
• W3152958227 cites W2116778443 @default.
• W3152958227 cites W2127070756 @default.
• W3152958227 cites W2129916970 @default.
• W3152958227 cites W2130229601 @default.
• W3152958227 cites W2136474306 @default.
• W3152958227 cites W2154171253 @default.
• W3152958227 cites W2161097861 @default.
• W3152958227 cites W2168851595 @default.
• W3152958227 cites W2170439480 @default.
• W3152958227 cites W2184221318 @default.
• W3152958227 cites W2237797200 @default.
• W3152958227 cites W2333085052 @default.
• W3152958227 cites W2396424530 @default.
• W3152958227 cites W2507513903 @default.
• W3152958227 cites W2521824087 @default.
• W3152958227 cites W2522210312 @default.
• W3152958227 cites W2571669554 @default.
• W3152958227 cites W2577027008 @default.
• W3152958227 cites W2612712744 @default.
• W3152958227 cites W2790660979 @default.
• W3152958227 cites W2801780797 @default.
• W3152958227 cites W2808296583 @default.
• W3152958227 cites W2809070489 @default.
• W3152958227 cites W2885284099 @default.
• W3152958227 cites W2900463496 @default.
• W3152958227 cites W2900552361 @default.
• W3152958227 cites W2901509748 @default.
• W3152958227 cites W2911259728 @default.
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• W3152958227 cites W2945781043 @default.
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• W3152958227 cites W3011405495 @default.
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• W3152958227 doi "https://doi.org/10.1111/cei.13607" @default.
• W3152958227 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/8374218" @default.
• W3152958227 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/33894002" @default.
• W3152958227 hasPublicationYear "2021" @default.
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