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• W3152960122 endingPage "1962" @default.
• W3152960122 startingPage "1962" @default.
• W3152960122 abstract "The clinical development of systemic treatments for hepatocellular carcinoma (HCC) has gained significant momentum in recent years. After the unexpected failure of the phase 3 trials testing the PD1-inhibitors nivolumab and pembrolizumab as monotherapy in advanced HCC, a multitude of trials employing different agents in various combinations and at different disease stages have been initiated. The first positive results reported for the combination of atezolizumab and bevacizumab, as the first line treatment of advanced HCC, will bring lasting change to the management of HCC and has increased the odds of success for alternative combination therapies. This review article seeks to provide clarity on the complex and evolving landscape of clinical trials on systemic treatments of HCC. It covers current trials which test various systemic treatments (i) in the first and second line in advanced HCC, (ii) in intermediate HCC, (iii) as adjuvant as well as (iv) neoadjuvant strategies, and (v) including immune interventions other than immune checkpoint inhibition." @default.
• W3152960122 created "2021-04-26" @default.
• W3152960122 creator A5009529288 @default.
• W3152960122 creator A5028882911 @default.
• W3152960122 date "2021-04-19" @default.
• W3152960122 modified "2023-10-07" @default.
• W3152960122 title "The Current Landscape of Clinical Trials for Systemic Treatment of HCC" @default.
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• W3152960122 doi "https://doi.org/10.3390/cancers13081962" @default.
• W3152960122 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/8073471" @default.
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• W3152960122 hasPublicationYear "2021" @default.
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