Matches in SemOpenAlex for { <https://semopenalex.org/work/W3153088655> ?p ?o ?g. }
- W3153088655 endingPage "1125" @default.
- W3153088655 startingPage "1113" @default.
- W3153088655 abstract "Abstract The American Cancer Society predicted more than 52 000 new cases of thyroid cancer in 2020, making it the most prevalent endocrine malignancy. Due to the approximately threefold higher incidence of thyroid cancer in women, we hypothesize that androgens and/or androgen receptors play a protective role and that thyroid cancer in men represents an escape from androgen‐mediated cell regulation. The analysis of androgen receptor (AR) expression in patient tissue samples identified a 2.7‐fold reduction in AR expression ( p < 0.005) in papillary thyroid cancer compared with matched, normal tissue. An in vitro cell model was developed by stably transfecting AR into 8505C undifferentiated thyroid cancer cells (resulting in clone 84E7). The addition of DHT to the clone 84E7 resulted in AR translocation into the nucleus and a 70% reduction in proliferation, with a shift in the cell cycle toward G1 arrest. RNASeq analysis revealed significant changes in mRNA levels associated with proliferation, cell cycle, and cell cycle regulation. Furthermore, androgen significantly decreased the levels of the G1‐associated cell cycle progression proteins cdc25a CDK6 CDK4 and CDK2 as well as increased the levels of the cell cycle inhibitors, p27 and p21. The data strongly suggest that DHT induces a G1 arrest in androgen‐responsive thyroid cancer cells. Together, these data support our hypothesis that AR/androgen may play a protective, antiproliferative role and are consistent with younger men having a lower incidence of thyroid cancer than women." @default.
- W3153088655 created "2021-04-26" @default.
- W3153088655 creator A5005243654 @default.
- W3153088655 creator A5006905292 @default.
- W3153088655 creator A5022034616 @default.
- W3153088655 creator A5029222555 @default.
- W3153088655 creator A5031855989 @default.
- W3153088655 creator A5037029599 @default.
- W3153088655 creator A5046671881 @default.
- W3153088655 creator A5049411755 @default.
- W3153088655 creator A5066991138 @default.
- W3153088655 creator A5076690266 @default.
- W3153088655 creator A5077139468 @default.
- W3153088655 creator A5085506767 @default.
- W3153088655 creator A5090715649 @default.
- W3153088655 date "2021-04-20" @default.
- W3153088655 modified "2023-10-18" @default.
- W3153088655 title "Androgen receptor activation decreases proliferation in thyroid cancer cells" @default.
- W3153088655 cites W1848939527 @default.
- W3153088655 cites W1963756521 @default.
- W3153088655 cites W1964033749 @default.
- W3153088655 cites W1965435467 @default.
- W3153088655 cites W1974121789 @default.
- W3153088655 cites W1974131940 @default.
- W3153088655 cites W1984185945 @default.
- W3153088655 cites W1994051894 @default.
- W3153088655 cites W1996318954 @default.
- W3153088655 cites W1997225060 @default.
- W3153088655 cites W2000041443 @default.
- W3153088655 cites W2008821525 @default.
- W3153088655 cites W2018173663 @default.
- W3153088655 cites W2021505095 @default.
- W3153088655 cites W2029399149 @default.
- W3153088655 cites W2030381529 @default.
- W3153088655 cites W2062219923 @default.
- W3153088655 cites W2062491181 @default.
- W3153088655 cites W2069792474 @default.
- W3153088655 cites W2072167545 @default.
- W3153088655 cites W2075812026 @default.
- W3153088655 cites W2076932702 @default.
- W3153088655 cites W2080839684 @default.
- W3153088655 cites W2090266106 @default.
- W3153088655 cites W2093637671 @default.
- W3153088655 cites W2096643907 @default.
- W3153088655 cites W2098179723 @default.
- W3153088655 cites W2107277218 @default.
- W3153088655 cites W2108892504 @default.
- W3153088655 cites W2111842257 @default.
- W3153088655 cites W2119644508 @default.
- W3153088655 cites W2122872753 @default.
- W3153088655 cites W2133465414 @default.
- W3153088655 cites W2154576579 @default.
- W3153088655 cites W2158217645 @default.
- W3153088655 cites W2165100613 @default.
- W3153088655 cites W2165530215 @default.
- W3153088655 cites W2999417355 @default.
- W3153088655 cites W3133644571 @default.
- W3153088655 cites W4294216483 @default.
- W3153088655 doi "https://doi.org/10.1002/jcb.29934" @default.
- W3153088655 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/33876852" @default.
- W3153088655 hasPublicationYear "2021" @default.
- W3153088655 type Work @default.
- W3153088655 sameAs 3153088655 @default.
- W3153088655 citedByCount "7" @default.
- W3153088655 countsByYear W31530886552021 @default.
- W3153088655 countsByYear W31530886552022 @default.
- W3153088655 countsByYear W31530886552023 @default.
- W3153088655 crossrefType "journal-article" @default.
- W3153088655 hasAuthorship W3153088655A5005243654 @default.
- W3153088655 hasAuthorship W3153088655A5006905292 @default.
- W3153088655 hasAuthorship W3153088655A5022034616 @default.
- W3153088655 hasAuthorship W3153088655A5029222555 @default.
- W3153088655 hasAuthorship W3153088655A5031855989 @default.
- W3153088655 hasAuthorship W3153088655A5037029599 @default.
- W3153088655 hasAuthorship W3153088655A5046671881 @default.
- W3153088655 hasAuthorship W3153088655A5049411755 @default.
- W3153088655 hasAuthorship W3153088655A5066991138 @default.
- W3153088655 hasAuthorship W3153088655A5076690266 @default.
- W3153088655 hasAuthorship W3153088655A5077139468 @default.
- W3153088655 hasAuthorship W3153088655A5085506767 @default.
- W3153088655 hasAuthorship W3153088655A5090715649 @default.
- W3153088655 hasConcept C120089663 @default.
- W3153088655 hasConcept C121608353 @default.
- W3153088655 hasConcept C126322002 @default.
- W3153088655 hasConcept C134018914 @default.
- W3153088655 hasConcept C199649820 @default.
- W3153088655 hasConcept C2777911890 @default.
- W3153088655 hasConcept C2779761222 @default.
- W3153088655 hasConcept C2780192828 @default.
- W3153088655 hasConcept C29537977 @default.
- W3153088655 hasConcept C502942594 @default.
- W3153088655 hasConcept C526584372 @default.
- W3153088655 hasConcept C54355233 @default.
- W3153088655 hasConcept C61367390 @default.
- W3153088655 hasConcept C62112901 @default.
- W3153088655 hasConcept C71315377 @default.
- W3153088655 hasConcept C71924100 @default.
- W3153088655 hasConcept C86803240 @default.