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• W3153158577 abstract "Orally administered curcumin has been found to have a moderate therapeutic effect on dyslipidemia and atherosclerosis. The present study was conducted to determine lipid-modulating and antiatherosclerosis effects of injectable curcumin in the rabbit model of atherosclerosis induced by a high cholesterol diet (HCD). New Zealand white male rabbits were fed on a normal chow enriched with 0.5% (w/w) cholesterol for 8 weeks. Atherosclerotic rabbits were randomly divided into three groups, including a control group receiving intravenous (IV) injection of the saline buffer, two treatment groups receiving IV administration of the injectable curcumin at low (1 mg/kg/week) and high (10 mg/kg/week) over 4 weeks. Plasma lipid parameters, including low-density lipoprotein cholesterol (LDL-C), high-density lipoprotein cholesterol (HDL-C), triglycerides (TG), and total cholesterol (TC) were measured. Aortic arch atherosclerotic lesions were assessed using hematoxylin and eosin (H&E) staining. The low dose of curcumin significantly reduced plasma levels of TC, LDL-C, and TG by −14.19 ± 5.19%, −6.22 ± 1.77%, and − 29.84 ± 10.14%, respectively, and increased HDL-C by 14.05 ± 6.39% (p < 0.05). High dose of curcumin exerted greater lipid-modifying effects, in which plasma levels of TC, LDL-C, and TG were significantly (p < 0.05) decreased by −56.59 ± 10.22%, −44.36 ± 3.24%, and − 25.92 ± 5.57%, respectively, and HDL-C was significantly increased by 36.24 ± 12.5%. H&E staining showed that the lesion severity was lowered significantly in the high dose (p = 0.03) but not significantly (p > 0.05) in the low-dose curcumin groups, compared to control rabbits. The median (interquartile range) of plaque grades in the high dose and low dose, and control groups was found to be 2 [2-3], 3 [2-3], and 4 [3-4], respectively. The injectable curcumin could significantly improve dyslipidemia and alleviate atherosclerotic lesion in HCD-induced atherosclerotic rabbits." @default.
• W3153158577 created "2021-04-26" @default.
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• W3153158577 date "2021-01-01" @default.
• W3153158577 modified "2023-10-18" @default.
• W3153158577 title "Intravenous Curcumin Mitigates Atherosclerosis Progression in Cholesterol-Fed Rabbits" @default.
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• W3153158577 cites W1971108528 @default.
• W3153158577 cites W1972179974 @default.
• W3153158577 cites W1976194786 @default.
• W3153158577 cites W1977777929 @default.
• W3153158577 cites W1983359741 @default.
• W3153158577 cites W1990437598 @default.
• W3153158577 cites W1990679071 @default.
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• W3153158577 cites W2019536742 @default.
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• W3153158577 cites W2024794025 @default.
• W3153158577 cites W2028743301 @default.
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• W3153158577 cites W2036747551 @default.
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• W3153158577 cites W2098049360 @default.
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• W3153158577 cites W2136389224 @default.
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• W3153158577 cites W2150799931 @default.
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• W3153158577 cites W2160081172 @default.
• W3153158577 cites W2165557537 @default.
• W3153158577 cites W2165605025 @default.
• W3153158577 cites W2169582126 @default.
• W3153158577 cites W2188441372 @default.
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• W3153158577 cites W2531364223 @default.
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• W3153158577 doi "https://doi.org/10.1007/978-3-030-64872-5_5" @default.
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• W3153158577 hasPublicationYear "2021" @default.
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