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- W3153179355 abstract "Objective: To study retrospectively, the significance of lesional location in patients with Multiple Sclerosis associated Seizures. Background: Up to 3–4 % of Multiple Sclerosis (MS) patients experience seizures during their disease course. This represents a much higher percentage than the prevalence of seizures in the general population. There is limited evidence regarding the mechanism, pathophysiology and Magnetic Resonance Imaging (MRI) parameters associated with MS related seizures. Design/Methods: 30 MS patients with subsequent seizures followed at Wayne State Neurology Clinic were included in this retrospective study. MRI scans completed after the first seizure and evaluated by a neuroradiologist were further analyzed. The lesions were categorized based on their location in cortical, subcortical and brainstem areas. Brainstem lesions were sub-categorized into midbrain, pons and medulla. Pearson’s chi-square test was performed to test the associations and odd’s ratio was calculated to measure the strength of associations. Results: 30 MS patients (relapsing remitting, n=20; secondary progressive, n=7; primary progressive, n=3) with mean age 54 years (SD=12 years) had subsequent seizures (time line= 1 to 28 years). Preliminary analysis showed that the presence of pontine demyelinating lesions have significant association with seizures (p=0.0024) among those MS patients with brainstem lesions. The odd’s ratio for this association was 16.5. However, the association was not significant for lesions located in midbrain and medulla. Furthermore, all patients had widespread distribution of cortical and subcortical lesions. Conclusions: MS related seizures are associated with pontine demyelinating lesions. Very few reports in the human and animal literature have described the role of the brainstem in epileptogenicity. The higher odd’s ratio for pontine lesions in MS patients with seizures suggests that these lesions may play a role in the modulation of epileptogenicity in this population. Larger prospective studies with serial neuroimaging can further evaluate their epileptogenic potential. Disclosure: Dr. Yarraguntla has nothing to disclose. Dr. Sriwastava has nothing to disclose. Dr. Marawar has nothing to disclose. Dr. Basha has nothing to disclose. Dr. Zutshi has nothing to disclose. Dr. Bernitsas has nothing to disclose." @default.
- W3153179355 created "2021-04-26" @default.
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- W3153179355 date "2018-04-10" @default.
- W3153179355 modified "2023-09-25" @default.
- W3153179355 title "Magnetic Resonance Imaging in Multiple Sclerosis associated Seizures (P3.345)" @default.
- W3153179355 hasPublicationYear "2018" @default.
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