FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3153226051> ?p ?o ?g. }

• W3153226051 endingPage "17219" @default.
• W3153226051 startingPage "17207" @default.
• W3153226051 abstract "Osteoclastic resorption of bone plays a central role in both osteoporosis and bone metastasis. A reliable in vitro assay that simulates osteoclastic resorption in vivo would significantly speed up the process of devel-oping effective therapeutic solutions for those diseases. Here we reported the development of a novel and robust nano-structured calcium phosphate coating with unique functions on the track-etched porous mem-brane by using an ammonia-induced mineralization (AiM) technique. The calcium phosphate coating uni-formly covers one side of the PET membrane enabling testing for osteoclastic resorption. The track-etched pores in the PET membrane allow calcium phosphate mineral pins to grow inside, which, on one hand, enhances coating integration with membrane substrate, and on the other hand provides diffusion channels for delivering drugs from the lower chamber of a double-chamber cell culture system. The applications of the processed calcium phosphate coating was first demonstrated as a drug screening device by using alen-dronate, a widely used drug for osteoporosis. It was confirmed that the delivery of alendronate significant-ly decreased both the number of monocyte-differentiated osteoclasts and coating resorption. To demon-strate the application in studying bone metastasis, we delivered PC3 prostate cancer conditioned medium and confirmed that both the differentiation of monocytes into osteoclasts and the osteoclastic resorption of the calcium phosphate coating were significantly enhanced. This novel assay thus provides a new platform for studying osteoclastic activities and assessing drug efficacy in vitro." @default.
• W3153226051 created "2021-04-26" @default.
• W3153226051 creator A5028394756 @default.
• W3153226051 creator A5033742520 @default.
• W3153226051 creator A5044547172 @default.
• W3153226051 creator A5055493931 @default.
• W3153226051 creator A5062470491 @default.
• W3153226051 creator A5062493663 @default.
• W3153226051 date "2021-04-12" @default.
• W3153226051 modified "2023-10-05" @default.
• W3153226051 title "An Ammonia-Induced Calcium Phosphate Nanostructure: A Potential Assay for Studying Osteoporosis and Bone Metastasis" @default.
• W3153226051 cites W1054124769 @default.
• W3153226051 cites W1944909911 @default.
• W3153226051 cites W1972416013 @default.
• W3153226051 cites W1972579411 @default.
• W3153226051 cites W1993114725 @default.
• W3153226051 cites W1994070755 @default.
• W3153226051 cites W2002992574 @default.
• W3153226051 cites W2003213153 @default.
• W3153226051 cites W2003287315 @default.
• W3153226051 cites W2005576117 @default.
• W3153226051 cites W2006582030 @default.
• W3153226051 cites W2013496911 @default.
• W3153226051 cites W2014712602 @default.
• W3153226051 cites W2019008302 @default.
• W3153226051 cites W2020151922 @default.
• W3153226051 cites W2021391717 @default.
• W3153226051 cites W2025703295 @default.
• W3153226051 cites W2037064574 @default.
• W3153226051 cites W2037824796 @default.
• W3153226051 cites W2039376950 @default.
• W3153226051 cites W2040295242 @default.
• W3153226051 cites W2045828273 @default.
• W3153226051 cites W2053273632 @default.
• W3153226051 cites W2060223628 @default.
• W3153226051 cites W2081498639 @default.
• W3153226051 cites W2087324367 @default.
• W3153226051 cites W2090183607 @default.
• W3153226051 cites W2090531876 @default.
• W3153226051 cites W2095258438 @default.
• W3153226051 cites W2097551160 @default.
• W3153226051 cites W2097743908 @default.
• W3153226051 cites W2103378167 @default.
• W3153226051 cites W2104173010 @default.
• W3153226051 cites W2105877024 @default.
• W3153226051 cites W2119352682 @default.
• W3153226051 cites W2121616190 @default.
• W3153226051 cites W2123346255 @default.
• W3153226051 cites W2124755056 @default.
• W3153226051 cites W2147867951 @default.
• W3153226051 cites W2156631550 @default.
• W3153226051 cites W2161962336 @default.
• W3153226051 cites W2162118093 @default.
• W3153226051 cites W2162723300 @default.
• W3153226051 cites W2185682830 @default.
• W3153226051 cites W2208935832 @default.
• W3153226051 cites W2288851772 @default.
• W3153226051 cites W2314408623 @default.
• W3153226051 cites W2321395279 @default.
• W3153226051 cites W2396599501 @default.
• W3153226051 cites W2529535353 @default.
• W3153226051 cites W2571476234 @default.
• W3153226051 cites W2792236131 @default.
• W3153226051 cites W2800086071 @default.
• W3153226051 cites W2809792348 @default.
• W3153226051 cites W2894491046 @default.
• W3153226051 cites W2896747888 @default.
• W3153226051 cites W2912588459 @default.
• W3153226051 cites W2919291970 @default.
• W3153226051 cites W2924903888 @default.
• W3153226051 cites W2967486422 @default.
• W3153226051 cites W3035966048 @default.
• W3153226051 cites W3037871209 @default.
• W3153226051 cites W3082488946 @default.
• W3153226051 doi "https://doi.org/10.1021/acsami.1c00495" @default.
• W3153226051 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/33845570" @default.
• W3153226051 hasPublicationYear "2021" @default.
• W3153226051 type Work @default.
• W3153226051 sameAs 3153226051 @default.
• W3153226051 citedByCount "4" @default.
• W3153226051 countsByYear W31532260512022 @default.
• W3153226051 countsByYear W31532260512023 @default.
• W3153226051 crossrefType "journal-article" @default.
• W3153226051 hasAuthorship W3153226051A5028394756 @default.
• W3153226051 hasAuthorship W3153226051A5033742520 @default.
• W3153226051 hasAuthorship W3153226051A5044547172 @default.
• W3153226051 hasAuthorship W3153226051A5055493931 @default.
• W3153226051 hasAuthorship W3153226051A5062470491 @default.
• W3153226051 hasAuthorship W3153226051A5062493663 @default.
• W3153226051 hasBestOaLocation W31532260512 @default.
• W3153226051 hasConcept C121608353 @default.
• W3153226051 hasConcept C12554922 @default.
• W3153226051 hasConcept C126322002 @default.
• W3153226051 hasConcept C136229726 @default.
• W3153226051 hasConcept C142724271 @default.
• W3153226051 hasConcept C146562846 @default.
• W3153226051 hasConcept C150903083 @default.
• W3153226051 hasConcept C185592680 @default.

• next