Matches in SemOpenAlex for { <https://semopenalex.org/work/W3153242718> ?p ?o ?g. }
- W3153242718 endingPage "1745" @default.
- W3153242718 startingPage "1732" @default.
- W3153242718 abstract "A high cholesterol diet (HCD) is known to cause metabolic dysregulation, oxidative stress, cardiovascular diseases and atherogenesis. Zingerone is a pharmacologically active component of dry ginger. Zingerone has been shown to have a wide range of pharmacological properties, including scavenging free radicals, high antioxidant activity, suppressing lipid peroxidation and anti-inflammatory. This study aimed to investigate the effects of Zingerone on HCD-induced atherosclerosis in rats.Animals were divided into four categories (n = 6). Group I: normal control, Group II: zingerone control (20 mg/kg b.wt.), group III: HCD-induced atherosclerosis, Group IV: HCD + zingerone, respectively, for 8 weeks.The HCD-fed rats resulted in a significant increase in an atherosclerotic lesion, lipid peroxidation, lipid profile, high-density lipoprotein concentration, cardiac markers, body weight, reduced antioxidant status, and displayed atherosclerosis. These findings were conventional by up-regulated expression of lipid regulatory genes like sterol-regulatory-element-binding protein-c (SREBP-c), fatty acid synthase (FAS), acetyl-CoA carboxylase (ACC), acetyl-CoA synthetase (ACS), liver X receptor-alpha (LXR-α), and down-regulated expression of acetyl-CoA oxidase (ACO), peroxisome proliferator-activated receptor-alpha (PPAR-α) and carnitine palmitoyl transferase-1 (CPT-1) in HCD-fed rats. These significant changes were observed in the zingerone-treated rats for the last 4 weeks.These findings suggest that zingerone reduced atherosclerosis by modulated the atherosclerotic lesion, lipid profile, antioxidant status and lipid regulatory gene expression in HCD-fed rats." @default.
- W3153242718 created "2021-04-26" @default.
- W3153242718 creator A5007357512 @default.
- W3153242718 creator A5007677073 @default.
- W3153242718 creator A5015614504 @default.
- W3153242718 creator A5021282823 @default.
- W3153242718 creator A5037537592 @default.
- W3153242718 creator A5043048265 @default.
- W3153242718 creator A5078220268 @default.
- W3153242718 date "2021-04-12" @default.
- W3153242718 modified "2023-09-27" @default.
- W3153242718 title "Protective effects of zingerone on high cholesterol diet-induced atherosclerosis through lipid regulatory signaling pathway" @default.
- W3153242718 cites W1573804402 @default.
- W3153242718 cites W1775749144 @default.
- W3153242718 cites W1880235892 @default.
- W3153242718 cites W1946263363 @default.
- W3153242718 cites W1963533730 @default.
- W3153242718 cites W1964607854 @default.
- W3153242718 cites W1966426389 @default.
- W3153242718 cites W1974658675 @default.
- W3153242718 cites W1982332921 @default.
- W3153242718 cites W1982403467 @default.
- W3153242718 cites W1989812175 @default.
- W3153242718 cites W1995382021 @default.
- W3153242718 cites W2006370393 @default.
- W3153242718 cites W2008428005 @default.
- W3153242718 cites W2015425984 @default.
- W3153242718 cites W2019653365 @default.
- W3153242718 cites W2019778386 @default.
- W3153242718 cites W2023131277 @default.
- W3153242718 cites W2023401600 @default.
- W3153242718 cites W2024851295 @default.
- W3153242718 cites W2034299473 @default.
- W3153242718 cites W2041423221 @default.
- W3153242718 cites W2056686398 @default.
- W3153242718 cites W2060194897 @default.
- W3153242718 cites W2061333433 @default.
- W3153242718 cites W2061679479 @default.
- W3153242718 cites W2072362233 @default.
- W3153242718 cites W2087609729 @default.
- W3153242718 cites W2096795975 @default.
- W3153242718 cites W2107914421 @default.
- W3153242718 cites W2115817762 @default.
- W3153242718 cites W2116404316 @default.
- W3153242718 cites W2118295695 @default.
- W3153242718 cites W2142415239 @default.
- W3153242718 cites W2143321563 @default.
- W3153242718 cites W2151216275 @default.
- W3153242718 cites W2159087408 @default.
- W3153242718 cites W2161201457 @default.
- W3153242718 cites W2163123322 @default.
- W3153242718 cites W2168526937 @default.
- W3153242718 cites W2170552843 @default.
- W3153242718 cites W2174107467 @default.
- W3153242718 cites W2209770937 @default.
- W3153242718 cites W2342246056 @default.
- W3153242718 cites W2566676430 @default.
- W3153242718 cites W2593325807 @default.
- W3153242718 cites W2599557486 @default.
- W3153242718 cites W2615088204 @default.
- W3153242718 cites W2775451099 @default.
- W3153242718 cites W2794342961 @default.
- W3153242718 cites W2806669042 @default.
- W3153242718 cites W3004718141 @default.
- W3153242718 cites W4252021281 @default.
- W3153242718 cites W68028631 @default.
- W3153242718 doi "https://doi.org/10.1177/09603271211006170" @default.
- W3153242718 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/33845646" @default.
- W3153242718 hasPublicationYear "2021" @default.
- W3153242718 type Work @default.
- W3153242718 sameAs 3153242718 @default.
- W3153242718 citedByCount "7" @default.
- W3153242718 countsByYear W31532427182021 @default.
- W3153242718 countsByYear W31532427182022 @default.
- W3153242718 countsByYear W31532427182023 @default.
- W3153242718 crossrefType "journal-article" @default.
- W3153242718 hasAuthorship W3153242718A5007357512 @default.
- W3153242718 hasAuthorship W3153242718A5007677073 @default.
- W3153242718 hasAuthorship W3153242718A5015614504 @default.
- W3153242718 hasAuthorship W3153242718A5021282823 @default.
- W3153242718 hasAuthorship W3153242718A5037537592 @default.
- W3153242718 hasAuthorship W3153242718A5043048265 @default.
- W3153242718 hasAuthorship W3153242718A5078220268 @default.
- W3153242718 hasConcept C126322002 @default.
- W3153242718 hasConcept C134018914 @default.
- W3153242718 hasConcept C185592680 @default.
- W3153242718 hasConcept C2776151105 @default.
- W3153242718 hasConcept C2778004101 @default.
- W3153242718 hasConcept C2778163477 @default.
- W3153242718 hasConcept C2779134260 @default.
- W3153242718 hasConcept C2780072125 @default.
- W3153242718 hasConcept C2780829032 @default.
- W3153242718 hasConcept C4733338 @default.
- W3153242718 hasConcept C48289651 @default.
- W3153242718 hasConcept C55493867 @default.
- W3153242718 hasConcept C57089818 @default.
- W3153242718 hasConcept C71924100 @default.
- W3153242718 hasConcept C86803240 @default.