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- W3153270385 endingPage "3780" @default.
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- W3153270385 abstract "While the pervasiveness of allostery in proteins is commonly accepted, we further show the generic nature of allosteric mechanisms by analyzing here transmembrane ion-channel viroporin 3a and RNA-dependent RNA polymerase (RdRp) from SARS-CoV-2 along with metabolic enzymes isocitrate dehydrogenase 1 (IDH1) and fumarate hydratase (FH) implicated in cancers. Using the previously developed structure-based statistical mechanical model of allostery (SBSMMA), we share our experience in analyzing the allosteric signaling, predicting latent allosteric sites, inducing and tuning targeted allosteric response, and exploring the allosteric effects of mutations. This, yet incomplete list of phenomenology, forms a complex and unique allosteric territory of protein function, which should be thoroughly explored. We propose a generic computational framework, which not only allows one to obtain a comprehensive allosteric control over proteins but also provides an opportunity to approach the fragment-based design of allosteric effectors and drug candidates. The advantages of allosteric drugs over traditional orthosteric compounds, complemented by the emerging role of the allosteric effects of mutations in the expansion of the cancer mutational landscape and in the increased mutability of viral proteins, leave no choice besides further extensive studies of allosteric mechanisms and their biomedical implications." @default.
- W3153270385 created "2021-04-26" @default.
- W3153270385 creator A5003572100 @default.
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- W3153270385 creator A5051203452 @default.
- W3153270385 creator A5072421875 @default.
- W3153270385 date "2021-04-12" @default.
- W3153270385 modified "2023-10-16" @default.
- W3153270385 title "Exploring the Allosteric Territory of Protein Function" @default.
- W3153270385 cites W1094391616 @default.
- W3153270385 cites W1595347157 @default.
- W3153270385 cites W1641120577 @default.
- W3153270385 cites W1900566389 @default.
- W3153270385 cites W1931354899 @default.
- W3153270385 cites W1967291345 @default.
- W3153270385 cites W1984259198 @default.
- W3153270385 cites W1984965754 @default.
- W3153270385 cites W1985925326 @default.
- W3153270385 cites W1998093640 @default.
- W3153270385 cites W1999605813 @default.
- W3153270385 cites W2003736358 @default.
- W3153270385 cites W2005004164 @default.
- W3153270385 cites W2005392755 @default.
- W3153270385 cites W2009581957 @default.
- W3153270385 cites W2011669324 @default.
- W3153270385 cites W2012369631 @default.
- W3153270385 cites W2014038272 @default.
- W3153270385 cites W2015610139 @default.
- W3153270385 cites W2020118170 @default.
- W3153270385 cites W2027869475 @default.
- W3153270385 cites W2032168101 @default.
- W3153270385 cites W2040827479 @default.
- W3153270385 cites W2049661341 @default.
- W3153270385 cites W2049682677 @default.
- W3153270385 cites W2050643839 @default.
- W3153270385 cites W2051992679 @default.
- W3153270385 cites W2064442639 @default.
- W3153270385 cites W2077912217 @default.
- W3153270385 cites W2078250280 @default.
- W3153270385 cites W2080452140 @default.
- W3153270385 cites W2084915350 @default.
- W3153270385 cites W2087395511 @default.
- W3153270385 cites W2094795801 @default.
- W3153270385 cites W2094851085 @default.
- W3153270385 cites W2115152262 @default.
- W3153270385 cites W2117455984 @default.
- W3153270385 cites W2124951199 @default.
- W3153270385 cites W2131860315 @default.
- W3153270385 cites W2134061682 @default.
- W3153270385 cites W2140943911 @default.
- W3153270385 cites W2142595184 @default.
- W3153270385 cites W2147339635 @default.
- W3153270385 cites W2148349600 @default.
- W3153270385 cites W2154249927 @default.
- W3153270385 cites W2159327390 @default.
- W3153270385 cites W2168432020 @default.
- W3153270385 cites W2195592873 @default.
- W3153270385 cites W2253581743 @default.
- W3153270385 cites W2288024449 @default.
- W3153270385 cites W2288312813 @default.
- W3153270385 cites W2294751189 @default.
- W3153270385 cites W2301723343 @default.
- W3153270385 cites W2468255124 @default.
- W3153270385 cites W2516773138 @default.
- W3153270385 cites W2519253539 @default.
- W3153270385 cites W2519928122 @default.
- W3153270385 cites W2527251618 @default.
- W3153270385 cites W2551870464 @default.
- W3153270385 cites W2557724778 @default.
- W3153270385 cites W2560058357 @default.
- W3153270385 cites W2583500948 @default.
- W3153270385 cites W2592980396 @default.
- W3153270385 cites W2642015544 @default.
- W3153270385 cites W2729103366 @default.
- W3153270385 cites W2744309759 @default.
- W3153270385 cites W2761066511 @default.
- W3153270385 cites W2762370213 @default.
- W3153270385 cites W2765958735 @default.
- W3153270385 cites W2767044445 @default.
- W3153270385 cites W2767842669 @default.
- W3153270385 cites W2769449822 @default.
- W3153270385 cites W2782408527 @default.
- W3153270385 cites W2795384715 @default.
- W3153270385 cites W2802091484 @default.
- W3153270385 cites W2802520483 @default.
- W3153270385 cites W2803294153 @default.
- W3153270385 cites W2805565876 @default.
- W3153270385 cites W2807983521 @default.
- W3153270385 cites W2810336146 @default.
- W3153270385 cites W2810768392 @default.
- W3153270385 cites W2885134480 @default.
- W3153270385 cites W2886463620 @default.
- W3153270385 cites W2887013503 @default.
- W3153270385 cites W2892596817 @default.
- W3153270385 cites W2894573839 @default.
- W3153270385 cites W2898529048 @default.
- W3153270385 cites W2898789672 @default.