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• W3153316781 endingPage "1807" @default.
• W3153316781 startingPage "1807" @default.
• W3153316781 abstract "Increasing evidence, particularly from animal studies, suggests that dopamine and GABA are important modulators of cognitive flexibility. In humans, increasing dopamine synthesis through its precursor tyrosine has been shown to result in performance improvements, but few studies have reported the effects of GABA supplementation in healthy participants. We conducted a double-blind, placebo-controlled, randomized experiment to test the interactive effects of tyrosine and GABA administration on two measures of cognitive flexibility, response inhibition and task switching. A total of 48 healthy volunteers were split into four groups (placebo, tyrosine alone, GABA alone, and tyrosine and GABA combined). They completed cognitive flexibility tasks at baseline and after drug administration. We found that tyrosine alone had no impact on the measures of cognitive flexibility, whereas GABA alone and in combination with tyrosine worsened task switching. Our results provide preliminary evidence that putative increases in GABA and dopamine synthesis do not interact to affect cognitive flexibility performance." @default.
• W3153316781 created "2021-04-26" @default.
• W3153316781 creator A5021877663 @default.
• W3153316781 creator A5052071602 @default.
• W3153316781 date "2021-04-21" @default.
• W3153316781 modified "2023-10-03" @default.
• W3153316781 title "GABA Supplementation Negatively Affects Cognitive Flexibility Independent of Tyrosine" @default.
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• W3153316781 doi "https://doi.org/10.3390/jcm10091807" @default.
• W3153316781 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/8122390" @default.
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• W3153316781 hasPublicationYear "2021" @default.
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