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- W3153331636 abstract "Abstract Mesenchymal stem/stromal cells (MSCs) are a promising resource for cell-based therapy because of their high immunomodulation ability, tropism towards inflamed and injured tissues, and their easy access and isolation. Currently, there are more than 1200 registered MSC clinical trials globally. However, a lack of standardized methods to characterize cell safety, efficacy, and biodistribution dramatically hinders the progress of MSC utility in clinical practice. In this review, we summarize the current state of MSC-based cell therapy, focusing on the systemic safety and biodistribution of MSCs. MSC-associated risks of tumor initiation and promotion and the underlying mechanisms of these risks are discussed. In addition, MSC biodistribution methodology and the pharmacokinetics and pharmacodynamics of cell therapies are addressed. Better understanding of the systemic safety and biodistribution of MSCs will facilitate future clinical applications of precision medicine using stem cells." @default.
- W3153331636 created "2021-04-26" @default.
- W3153331636 creator A5002610764 @default.
- W3153331636 creator A5009541856 @default.
- W3153331636 creator A5027192230 @default.
- W3153331636 creator A5028074284 @default.
- W3153331636 creator A5056774320 @default.
- W3153331636 creator A5065102952 @default.
- W3153331636 creator A5071853087 @default.
- W3153331636 creator A5091377565 @default.
- W3153331636 date "2021-04-14" @default.
- W3153331636 modified "2023-10-13" @default.
- W3153331636 title "Mesenchymal stem/stromal cell-based therapy: mechanism, systemic safety and biodistribution for precision clinical applications" @default.
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