Matches in SemOpenAlex for { <https://semopenalex.org/work/W3153349428> ?p ?o ?g. }
- W3153349428 endingPage "e1009496" @default.
- W3153349428 startingPage "e1009496" @default.
- W3153349428 abstract "LINE-1 (L1) retrotransposons are autonomous transposable elements that can affect gene expression and genome integrity. Potential consequences of exogenous viral infections for L1 activity have not been studied to date. Here, we report that hepatitis C virus (HCV) infection causes a significant increase of endogenous L1-encoded ORF1 protein (L1ORF1p) levels and translocation of L1ORF1p to HCV assembly sites at lipid droplets. HCV replication interferes with retrotransposition of engineered L1 reporter elements, which correlates with HCV RNA-induced formation of stress granules and can be partially rescued by knockdown of the stress granule protein G3BP1. Upon HCV infection, L1ORF1p localizes to stress granules, associates with HCV core in an RNA-dependent manner and translocates to lipid droplets. While HCV infection has a negative effect on L1 mobilization, L1ORF1p neither restricts nor promotes HCV infection. In summary, our data demonstrate that HCV infection causes an increase of endogenous L1 protein levels and that the observed restriction of retrotransposition of engineered L1 reporter elements is caused by sequestration of L1ORF1p in HCV-induced stress granules." @default.
- W3153349428 created "2021-04-26" @default.
- W3153349428 creator A5013546995 @default.
- W3153349428 creator A5041106301 @default.
- W3153349428 creator A5068891297 @default.
- W3153349428 creator A5078875423 @default.
- W3153349428 date "2021-04-19" @default.
- W3153349428 modified "2023-10-12" @default.
- W3153349428 title "Hepatitis C virus infection restricts human LINE-1 retrotransposition in hepatoma cells" @default.
- W3153349428 cites W1509378838 @default.
- W3153349428 cites W1538573061 @default.
- W3153349428 cites W1575680716 @default.
- W3153349428 cites W1755605051 @default.
- W3153349428 cites W1835730169 @default.
- W3153349428 cites W1866458240 @default.
- W3153349428 cites W1944771638 @default.
- W3153349428 cites W1957867949 @default.
- W3153349428 cites W1965141089 @default.
- W3153349428 cites W1967266019 @default.
- W3153349428 cites W1968468219 @default.
- W3153349428 cites W1977771685 @default.
- W3153349428 cites W1978325079 @default.
- W3153349428 cites W1979333281 @default.
- W3153349428 cites W1985575613 @default.
- W3153349428 cites W1986319478 @default.
- W3153349428 cites W1988495745 @default.
- W3153349428 cites W1990015734 @default.
- W3153349428 cites W1991333931 @default.
- W3153349428 cites W1991792191 @default.
- W3153349428 cites W1993170858 @default.
- W3153349428 cites W1998581442 @default.
- W3153349428 cites W1999355295 @default.
- W3153349428 cites W2002190096 @default.
- W3153349428 cites W2002735295 @default.
- W3153349428 cites W2003579943 @default.
- W3153349428 cites W2007506415 @default.
- W3153349428 cites W2007589425 @default.
- W3153349428 cites W2008075099 @default.
- W3153349428 cites W2009603499 @default.
- W3153349428 cites W2009761723 @default.
- W3153349428 cites W2010268348 @default.
- W3153349428 cites W2015415562 @default.
- W3153349428 cites W2016732725 @default.
- W3153349428 cites W2018177575 @default.
- W3153349428 cites W2018434707 @default.
- W3153349428 cites W2023645777 @default.
- W3153349428 cites W2031602764 @default.
- W3153349428 cites W2035120673 @default.
- W3153349428 cites W2040154453 @default.
- W3153349428 cites W2044193462 @default.
- W3153349428 cites W2046750712 @default.
- W3153349428 cites W2050937759 @default.
- W3153349428 cites W2055508399 @default.
- W3153349428 cites W2057967679 @default.
- W3153349428 cites W2059670505 @default.
- W3153349428 cites W2061395055 @default.
- W3153349428 cites W2061569670 @default.
- W3153349428 cites W2062250400 @default.
- W3153349428 cites W2064629259 @default.
- W3153349428 cites W2065148518 @default.
- W3153349428 cites W2066705292 @default.
- W3153349428 cites W2068584800 @default.
- W3153349428 cites W2069463866 @default.
- W3153349428 cites W2073973240 @default.
- W3153349428 cites W2074897380 @default.
- W3153349428 cites W2075224242 @default.
- W3153349428 cites W2076699592 @default.
- W3153349428 cites W2076945600 @default.
- W3153349428 cites W2077053535 @default.
- W3153349428 cites W2077707253 @default.
- W3153349428 cites W2079599967 @default.
- W3153349428 cites W2080543752 @default.
- W3153349428 cites W2086739233 @default.
- W3153349428 cites W2088207658 @default.
- W3153349428 cites W2088617449 @default.
- W3153349428 cites W2089640290 @default.
- W3153349428 cites W2089962959 @default.
- W3153349428 cites W2091279754 @default.
- W3153349428 cites W2092288031 @default.
- W3153349428 cites W2093278823 @default.
- W3153349428 cites W2093606206 @default.
- W3153349428 cites W2095163173 @default.
- W3153349428 cites W2098079636 @default.
- W3153349428 cites W2098474039 @default.
- W3153349428 cites W2098678281 @default.
- W3153349428 cites W2101731216 @default.
- W3153349428 cites W2102773855 @default.
- W3153349428 cites W2106551806 @default.
- W3153349428 cites W2113973815 @default.
- W3153349428 cites W2114924552 @default.
- W3153349428 cites W2115594110 @default.
- W3153349428 cites W2118926211 @default.
- W3153349428 cites W2120034162 @default.
- W3153349428 cites W2121772424 @default.
- W3153349428 cites W2124036670 @default.
- W3153349428 cites W2131212168 @default.
- W3153349428 cites W2131912436 @default.
- W3153349428 cites W2140197300 @default.