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• W3153371337 endingPage "4866" @default.
• W3153371337 startingPage "4850" @default.
• W3153371337 abstract "Taste neurons are functionally and molecularly diverse, but their morphologic diversity remains completely unexplored. Using sparse cell genetic labeling, we provide the first reconstructions of peripheral taste neurons. The branching characteristics across 96 taste neurons show surprising diversity in their complexities. Individual neurons had 1-17 separate arbors entering between one and seven taste buds, 18 of these neurons also innervated non-taste epithelia. Axon branching characteristics are similar in gustatory neurons from male and female mice. Cluster analysis separated the neurons into four groups according to branch complexity. The primary difference between clusters was the amount of the nerve fiber within the taste bud available to contact taste-transducing cells. Consistently, we found that the maximum number of taste-transducing cells capable of providing convergent input onto individual gustatory neurons varied with a range of 1-22 taste-transducing cells. Differences in branching characteristics across neurons indicate that some neurons likely receive input from a larger number of taste-transducing cells than other neurons (differential convergence). By dividing neurons into two groups based on the type of taste-transducing cell most contacted, we found that neurons contacting primarily sour transducing cells were more heavily branched than those contacting primarily sweet/bitter/umami transducing cells. This suggests that neuron morphologies may differ across functional taste quality. However, the considerable remaining variability within each group also suggests differential convergence within each functional taste quality. Each possibility has functional implications for the system.SIGNIFICANCE STATEMENT Taste neurons are considered relay cells, communicating information from taste-transducing cells to the brain, without variation in morphology. By reconstructing peripheral taste neuron morphologies for the first time, we found that some peripheral gustatory neurons are simply branched, and can receive input from only a few taste-transducing cells. Other taste neurons are heavily branched, contacting many more taste-transducing cells than simply branched neurons. Based on the type of taste-transducing cell contacted, branching characteristics are predicted to differ across (and within) quality types (sweet/bitter/umami vs sour). Therefore, functional differences between neurons likely depends on the number of taste-transducing cells providing input and not just the type of cell providing input." @default.
• W3153371337 created "2021-04-26" @default.
• W3153371337 creator A5001306228 @default.
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• W3153371337 date "2021-04-19" @default.
• W3153371337 modified "2023-10-01" @default.
• W3153371337 title "Variable Branching Characteristics of Peripheral Taste Neurons Indicates Differential Convergence" @default.
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• W3153371337 cites W147037875 @default.
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• W3153371337 cites W1961136897 @default.
• W3153371337 cites W1965193260 @default.
• W3153371337 cites W1967230265 @default.
• W3153371337 cites W1968174567 @default.
• W3153371337 cites W1973214847 @default.
• W3153371337 cites W1979060547 @default.
• W3153371337 cites W1981501538 @default.
• W3153371337 cites W1981567753 @default.
• W3153371337 cites W1983022653 @default.
• W3153371337 cites W1987198829 @default.
• W3153371337 cites W1998956069 @default.
• W3153371337 cites W1999882796 @default.
• W3153371337 cites W2011147991 @default.
• W3153371337 cites W2012265686 @default.
• W3153371337 cites W2015957420 @default.
• W3153371337 cites W2015977442 @default.
• W3153371337 cites W2023939486 @default.
• W3153371337 cites W2030085291 @default.
• W3153371337 cites W2030774440 @default.
• W3153371337 cites W2034780781 @default.
• W3153371337 cites W2038573621 @default.
• W3153371337 cites W2042475399 @default.
• W3153371337 cites W2046732949 @default.
• W3153371337 cites W2047012091 @default.
• W3153371337 cites W2047804311 @default.
• W3153371337 cites W2055766527 @default.
• W3153371337 cites W2070348637 @default.
• W3153371337 cites W2072112596 @default.
• W3153371337 cites W2077374317 @default.
• W3153371337 cites W2080340979 @default.
• W3153371337 cites W2089471603 @default.
• W3153371337 cites W2091760668 @default.
• W3153371337 cites W2097933114 @default.
• W3153371337 cites W2098729010 @default.
• W3153371337 cites W2120343001 @default.
• W3153371337 cites W2120673416 @default.
• W3153371337 cites W2143020449 @default.
• W3153371337 cites W2143191421 @default.
• W3153371337 cites W2145788577 @default.
• W3153371337 cites W2150074590 @default.
• W3153371337 cites W2153406367 @default.
• W3153371337 cites W2165067116 @default.
• W3153371337 cites W2220753543 @default.
• W3153371337 cites W2260182572 @default.
• W3153371337 cites W2285106383 @default.
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• W3153371337 cites W2346645055 @default.
• W3153371337 cites W2402412060 @default.
• W3153371337 cites W2418715341 @default.
• W3153371337 cites W2492830730 @default.
• W3153371337 cites W2605317859 @default.
• W3153371337 cites W2617667835 @default.
• W3153371337 cites W2695848533 @default.
• W3153371337 cites W2739714473 @default.
• W3153371337 cites W2742748694 @default.
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• W3153371337 cites W2758667792 @default.
• W3153371337 cites W2765096138 @default.
• W3153371337 cites W2769068417 @default.
• W3153371337 cites W2802984476 @default.
• W3153371337 cites W2804862861 @default.
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• W3153371337 doi "https://doi.org/10.1523/jneurosci.1935-20.2021" @default.
• W3153371337 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/8260161" @default.
• W3153371337 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/33875572" @default.
• W3153371337 hasPublicationYear "2021" @default.
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