FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3153397492> ?p ?o ?g. }

• W3153397492 abstract "Background The overlap between cancer and cardiovascular care continues to expand, with intersections emerging before, during, and following cancer therapies. To date, emphasis has been placed on how cancer therapeutics influence downstream cardiac health. However, whether active malignancy itself influences chamber volumes, function, or overall myocardial tissue health remains uncertain. We sought to perform a comprehensive cardiovascular magnetic resonance-based evaluation of cardiac health in patients with chemotherapy-naïve cancer with comparison with a healthy volunteer population. Methods and Results Three-hundred and eighty-one patients with active breast cancer or lymphoma before cardiotoxic chemotherapy exposure were recruited in addition to 102 healthy volunteers. Both cohorts underwent standardized cardiovascular magnetic resonance imaging with quantification of chamber volumes, ejection fraction, and native myocardial T1. Left ventricular mechanics were incrementally assessed using three-dimensional myocardial deformation analysis, providing global longitudinal, circumferential, radial, and principal peak-systolic strain amplitude and systolic strain rate. The mean age of patients with cancer was 53.8±13.4 years; 79% being women. Despite similar left ventricular ejection fraction, patients with cancer showed smaller chambers, increased strain amplitude, and systolic strain rate in both conventional and principal directions, and elevated native T1 versus sex-matched healthy volunteers. Adjusting for age, sex, hypertension, and diabetes mellitus, the presence of cancer remained associated with these cardiovascular magnetic resonance parameters. Conclusions The presence of cancer is independently associated with alterations in cardiac chamber size, function, and objective markers of tissue health. Dedicated research is warranted to elucidate pathophysiologic mechanisms underlying these findings and to explore their relevance to the management of patients with cancer referred for cardiotoxic therapies." @default.
• W3153397492 created "2021-04-26" @default.
• W3153397492 creator A5005095514 @default.
• W3153397492 creator A5005318646 @default.
• W3153397492 creator A5012370657 @default.
• W3153397492 creator A5013138908 @default.
• W3153397492 creator A5016151180 @default.
• W3153397492 creator A5017889093 @default.
• W3153397492 creator A5020770877 @default.
• W3153397492 creator A5033370632 @default.
• W3153397492 creator A5035061725 @default.
• W3153397492 creator A5035878978 @default.
• W3153397492 creator A5039850848 @default.
• W3153397492 creator A5049316134 @default.
• W3153397492 creator A5052353077 @default.
• W3153397492 creator A5060533661 @default.
• W3153397492 creator A5063848860 @default.
• W3153397492 creator A5064095566 @default.
• W3153397492 creator A5070858953 @default.
• W3153397492 creator A5074736340 @default.
• W3153397492 creator A5088301591 @default.
• W3153397492 creator A5089573796 @default.
• W3153397492 creator A5091744479 @default.
• W3153397492 date "2021-05-04" @default.
• W3153397492 modified "2023-10-15" @default.
• W3153397492 title "Effect of Active Cancer on the Cardiac Phenotype: A Cardiac Magnetic Resonance Imaging‐Based Study of Myocardial Tissue Health and Deformation in Patients With Chemotherapy‐Naïve Cancer" @default.
• W3153397492 cites W1977992465 @default.
• W3153397492 cites W1986804424 @default.
• W3153397492 cites W1990891357 @default.
• W3153397492 cites W2011232757 @default.
• W3153397492 cites W2029542561 @default.
• W3153397492 cites W2117828918 @default.
• W3153397492 cites W2129655528 @default.
• W3153397492 cites W2132401137 @default.
• W3153397492 cites W2132769254 @default.
• W3153397492 cites W2133304247 @default.
• W3153397492 cites W2150303501 @default.
• W3153397492 cites W2151254481 @default.
• W3153397492 cites W2169013021 @default.
• W3153397492 cites W2172458185 @default.
• W3153397492 cites W2222642872 @default.
• W3153397492 cites W2262026292 @default.
• W3153397492 cites W2516408494 @default.
• W3153397492 cites W2517647639 @default.
• W3153397492 cites W2604558301 @default.
• W3153397492 cites W2731551298 @default.
• W3153397492 cites W2755254134 @default.
• W3153397492 cites W2768449389 @default.
• W3153397492 cites W2803610648 @default.
• W3153397492 cites W2808262624 @default.
• W3153397492 cites W2808928244 @default.
• W3153397492 cites W2885097489 @default.
• W3153397492 cites W2885782244 @default.
• W3153397492 cites W2947377711 @default.
• W3153397492 cites W2959497269 @default.
• W3153397492 cites W2970631311 @default.
• W3153397492 cites W2993119581 @default.
• W3153397492 cites W2995840971 @default.
• W3153397492 cites W3009567867 @default.
• W3153397492 cites W3018708948 @default.
• W3153397492 cites W3042004622 @default.
• W3153397492 cites W3048899545 @default.
• W3153397492 doi "https://doi.org/10.1161/jaha.120.019811" @default.
• W3153397492 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/8200726" @default.
• W3153397492 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/33878890" @default.
• W3153397492 hasPublicationYear "2021" @default.
• W3153397492 type Work @default.
• W3153397492 sameAs 3153397492 @default.
• W3153397492 citedByCount "14" @default.
• W3153397492 countsByYear W31533974922021 @default.
• W3153397492 countsByYear W31533974922022 @default.
• W3153397492 countsByYear W31533974922023 @default.
• W3153397492 crossrefType "journal-article" @default.
• W3153397492 hasAuthorship W3153397492A5005095514 @default.
• W3153397492 hasAuthorship W3153397492A5005318646 @default.
• W3153397492 hasAuthorship W3153397492A5012370657 @default.
• W3153397492 hasAuthorship W3153397492A5013138908 @default.
• W3153397492 hasAuthorship W3153397492A5016151180 @default.
• W3153397492 hasAuthorship W3153397492A5017889093 @default.
• W3153397492 hasAuthorship W3153397492A5020770877 @default.
• W3153397492 hasAuthorship W3153397492A5033370632 @default.
• W3153397492 hasAuthorship W3153397492A5035061725 @default.
• W3153397492 hasAuthorship W3153397492A5035878978 @default.
• W3153397492 hasAuthorship W3153397492A5039850848 @default.
• W3153397492 hasAuthorship W3153397492A5049316134 @default.
• W3153397492 hasAuthorship W3153397492A5052353077 @default.
• W3153397492 hasAuthorship W3153397492A5060533661 @default.
• W3153397492 hasAuthorship W3153397492A5063848860 @default.
• W3153397492 hasAuthorship W3153397492A5064095566 @default.
• W3153397492 hasAuthorship W3153397492A5070858953 @default.
• W3153397492 hasAuthorship W3153397492A5074736340 @default.
• W3153397492 hasAuthorship W3153397492A5088301591 @default.
• W3153397492 hasAuthorship W3153397492A5089573796 @default.
• W3153397492 hasAuthorship W3153397492A5091744479 @default.
• W3153397492 hasBestOaLocation W31533974921 @default.
• W3153397492 hasConcept C121608353 @default.
• W3153397492 hasConcept C126322002 @default.
• W3153397492 hasConcept C126838900 @default.
• W3153397492 hasConcept C143409427 @default.
• W3153397492 hasConcept C164705383 @default.

• next