FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3153445091> ?p ?o ?g. }

• W3153445091 endingPage "1079" @default.
• W3153445091 startingPage "1067" @default.
• W3153445091 abstract "Abstract Objective The malignant phenotypes of cancer are defined not only by its intrinsic tumor cells but also by the tumor-infiltrating immune cells activated and recruited to the cancer microenvironment. However, a comprehensive introduction of gastric cancer immune cell infiltration has not been identified so far. Methods In this study, we comprehensively analyzed the tumor-infiltrating immune cells abundance in gastric cancer for the first time by CIBERSORT. The meta-analysis, single-sample gene set enrichment analysis and hierarchical agglomerative clustering were used to measure and evaluate the respective proportions of 22 cell types of immune infiltration using normalized gene expression data. The fraction of tumor-infiltrating immune cells subpopulations was also evaluated to determine the associations with clinical features and molecular subtypes. Results Tumor-infiltrating immune cells are extensively involved in the pathogenesis and development of the gastric cancer. We discovered Tfh and activated CD4+ memory T cells were associated with poorer overall survival and Progression-free survival (PFS), but that naïve B cells were opposite for PFS. Unsupervised clustering analysis revealed there existed three tumor-infiltrating immune cells subgroups with distinct survival patterns. Specially, cluster 1 showed significantly better clinical outcome than other two clusters. Conclusions Collectively, our data explored the differences of tumor-infiltrating immune cells in gastric cancer, and these variations were likely to be important clues for prognosis and management of its future clinical implementation." @default.
• W3153445091 created "2021-04-26" @default.
• W3153445091 creator A5021142089 @default.
• W3153445091 creator A5049165428 @default.
• W3153445091 creator A5073056651 @default.
• W3153445091 creator A5086048795 @default.
• W3153445091 date "2021-04-23" @default.
• W3153445091 modified "2023-10-13" @default.
• W3153445091 title "Patterns of immune infiltration in gastric cancer and their clinical significance" @default.
• W3153445091 cites W1890890118 @default.
• W3153445091 cites W1985987855 @default.
• W3153445091 cites W2000378305 @default.
• W3153445091 cites W2010253580 @default.
• W3153445091 cites W2020541351 @default.
• W3153445091 cites W2022495797 @default.
• W3153445091 cites W2028433016 @default.
• W3153445091 cites W2037900813 @default.
• W3153445091 cites W2040871044 @default.
• W3153445091 cites W2047027176 @default.
• W3153445091 cites W2081448273 @default.
• W3153445091 cites W2098153894 @default.
• W3153445091 cites W2115521447 @default.
• W3153445091 cites W2116554142 @default.
• W3153445091 cites W2119173974 @default.
• W3153445091 cites W2126547130 @default.
• W3153445091 cites W2128416049 @default.
• W3153445091 cites W2129229830 @default.
• W3153445091 cites W2130430382 @default.
• W3153445091 cites W2152061559 @default.
• W3153445091 cites W2154459623 @default.
• W3153445091 cites W2159560463 @default.
• W3153445091 cites W2160178368 @default.
• W3153445091 cites W2160834915 @default.
• W3153445091 cites W2299919100 @default.
• W3153445091 cites W2493682719 @default.
• W3153445091 cites W2522869448 @default.
• W3153445091 cites W2523638453 @default.
• W3153445091 cites W2527905628 @default.
• W3153445091 cites W2530700542 @default.
• W3153445091 cites W2535969070 @default.
• W3153445091 cites W2567668099 @default.
• W3153445091 cites W2583982957 @default.
• W3153445091 cites W2602826792 @default.
• W3153445091 cites W2747359356 @default.
• W3153445091 cites W2749042075 @default.
• W3153445091 cites W2772062014 @default.
• W3153445091 cites W2783288907 @default.
• W3153445091 cites W2793364080 @default.
• W3153445091 cites W2802285660 @default.
• W3153445091 cites W2806670396 @default.
• W3153445091 cites W2886006442 @default.
• W3153445091 cites W2900032527 @default.
• W3153445091 cites W2917837889 @default.
• W3153445091 cites W2969443468 @default.
• W3153445091 cites W52273448 @default.
• W3153445091 doi "https://doi.org/10.1093/jjco/hyab054" @default.
• W3153445091 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/33890063" @default.
• W3153445091 hasPublicationYear "2021" @default.
• W3153445091 type Work @default.
• W3153445091 sameAs 3153445091 @default.
• W3153445091 citedByCount "2" @default.
• W3153445091 countsByYear W31534450912022 @default.
• W3153445091 crossrefType "journal-article" @default.
• W3153445091 hasAuthorship W3153445091A5021142089 @default.
• W3153445091 hasAuthorship W3153445091A5049165428 @default.
• W3153445091 hasAuthorship W3153445091A5073056651 @default.
• W3153445091 hasAuthorship W3153445091A5086048795 @default.
• W3153445091 hasBestOaLocation W31534450911 @default.
• W3153445091 hasConcept C121332964 @default.
• W3153445091 hasConcept C121608353 @default.
• W3153445091 hasConcept C126322002 @default.
• W3153445091 hasConcept C143998085 @default.
• W3153445091 hasConcept C153400128 @default.
• W3153445091 hasConcept C203014093 @default.
• W3153445091 hasConcept C2776107976 @default.
• W3153445091 hasConcept C2777701055 @default.
• W3153445091 hasConcept C2778326572 @default.
• W3153445091 hasConcept C502942594 @default.
• W3153445091 hasConcept C71924100 @default.
• W3153445091 hasConcept C8891405 @default.
• W3153445091 hasConcept C96232424 @default.
• W3153445091 hasConcept C97355855 @default.
• W3153445091 hasConceptScore W3153445091C121332964 @default.
• W3153445091 hasConceptScore W3153445091C121608353 @default.
• W3153445091 hasConceptScore W3153445091C126322002 @default.
• W3153445091 hasConceptScore W3153445091C143998085 @default.
• W3153445091 hasConceptScore W3153445091C153400128 @default.
• W3153445091 hasConceptScore W3153445091C203014093 @default.
• W3153445091 hasConceptScore W3153445091C2776107976 @default.
• W3153445091 hasConceptScore W3153445091C2777701055 @default.
• W3153445091 hasConceptScore W3153445091C2778326572 @default.
• W3153445091 hasConceptScore W3153445091C502942594 @default.
• W3153445091 hasConceptScore W3153445091C71924100 @default.
• W3153445091 hasConceptScore W3153445091C8891405 @default.
• W3153445091 hasConceptScore W3153445091C96232424 @default.
• W3153445091 hasConceptScore W3153445091C97355855 @default.
• W3153445091 hasFunder F4320321001 @default.
• W3153445091 hasIssue "7" @default.

• next