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• W3153455871 abstract "Oxidative stress plays a significant role in the pathogenesis of heart failure (HF). The aim of the study was to investigate the prognostic value of oxidation-reduction (redox) markers in patients with HF due to ischemic and nonischemic cardiomyopathy. The study included 707 patients of HF allocated into two groups depending on ethology: ischemic cardiomyopathy (ICM) ( <math xmlns=http://www.w3.org/1998/Math/MathML id=M1> <mi>n</mi> <mo>=</mo> <mn>435</mn> </math> ) and nonischemic cardiomyopathy (nICM) ( <math xmlns=http://www.w3.org/1998/Math/MathML id=M2> <mi>n</mi> <mo>=</mo> <mn>272</mn> </math> ), who were followed up for one year. The endpoint occurrence (mortality or heart transplantation) in a 1-year follow-up was similar in the ICM and nICM group. The predictive value of endpoint occurrence of oxidative stress biomarkers such as the serum protein sulfhydryl groups (PSH), malondialdehyde (MDA), uric acid (UA), bilirubin, and MDA/PSH ratio and other clinical and laboratory data were assessed in both groups (ICM and nICM) separately using univariate and multivariate Cox regression analyses. In multivariate analysis, the higher concentrations of UA ( <math xmlns=http://www.w3.org/1998/Math/MathML id=M3> <mi>p</mi> <mo>=</mo> <mn>0.015</mn> </math> , <math xmlns=http://www.w3.org/1998/Math/MathML id=M4> <mtext>HR</mtext> <mo>=</mo> <mn>1.024</mn> </math> , 95% CI (1.005-1.044)) and MDA ( <math xmlns=http://www.w3.org/1998/Math/MathML id=M5> <mi>p</mi> <mo>=</mo> <mn>0.004</mn> </math> , <math xmlns=http://www.w3.org/1998/Math/MathML id=M6> <mtext>HR</mtext> <mo>=</mo> <mn>2.202</mn> </math> , 95% CI (1.296-3.741)) were significantly associated with adverse prognosis in patients with ICM. Contrastingly, in patients with nICM, we observed that higher bilirubin concentration ( <math xmlns=http://www.w3.org/1998/Math/MathML id=M7> <mi>p</mi> <mo>=</mo> <mn>0.026</mn> </math> , <math xmlns=http://www.w3.org/1998/Math/MathML id=M8> <mtext>HR</mtext> <mo>=</mo> <mn>1.034</mn> </math> , 95% CI (1.004-1.064)) and MDA/PSH ratio ( <math xmlns=http://www.w3.org/1998/Math/MathML id=M9> <mi>p</mi> <mo>=</mo> <mn>0.034</mn> </math> , <math xmlns=http://www.w3.org/1998/Math/MathML id=M10> <mtext>HR</mtext> <mo>=</mo> <mn>3.360</mn> </math> , 95% CI (1.096-10.302)) were significantly associated with increased risk of death or HT. The results showed the association of different oxidative biomarkers on the unfavorable course of heart failure depending on etiology." @default.
• W3153455871 created "2021-04-26" @default.
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• W3153455871 date "2021-04-15" @default.
• W3153455871 modified "2023-10-16" @default.
• W3153455871 title "Serum Sulfhydryl Groups, Malondialdehyde, Uric Acid, and Bilirubin as Predictors of Adverse Outcome in Heart Failure Patients due to Ischemic or Nonischemic Cardiomyopathy" @default.
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• W3153455871 doi "https://doi.org/10.1155/2021/6693405" @default.
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