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- W3153628208 abstract "Background: Early treatment of neonatal biliary atresia (BA) and other end-stage liver diseases can delay or prevent the necessity of liver transplantation (LT). The establishment of a standardized clinical pediatric liver transplantation (PLT) biobank is the prerequisite for scientific research, which helps to provide a qualified sample resource platform for research. Methods: Following standardized procedures to establish biobanks, the operational processes and quality control system were formulated. Liver tissue, blood, and stool samples undergoing LT were regularly collected, managed, and stored. Systematic management was conducted in collected specimens and corresponding clinical information. Results: Since implementation in August 2018, we have enrolled 49 unique subjects (0-18 years of age); the biobank contains nearly 3000 biospecimen aliquots. The most common LT diagnosis is BA (61.23%). Conclusion: The establishment of this biobank is a valuable resource that incorporates detailed clinical and biological information. It will help accelerate the pace of PLT discovery research. ClinicalTrials.gov ID: NCT04477967." @default.
- W3153628208 created "2021-04-26" @default.
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- W3153628208 date "2021-04-01" @default.
- W3153628208 modified "2023-09-30" @default.
- W3153628208 title "Study Protocol: Design and Implementation of the Pediatric Liver Transplantation Biobank" @default.
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- W3153628208 doi "https://doi.org/10.1089/bio.2020.0128" @default.
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