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• W3153731385 abstract "Since ivabradine (IVA) inhibits hyperpolarization-activated cyclic nucleotide-gated channels, interactions among the sympathetic effect, vagal effect, and IVA can occur in the control of heart rate (HR). To remove the sympathetic effect, we estimated the transfer function from vagal nerve stimulation to HR under β-blockade in anesthetized rats. IVA augmented the high-frequency dynamic gain during low- and moderate-intensity vagal nerve stimulation. Untethering the hyperpolarizing effect of acetylcholine-sensitive potassium channels after IVA may be a possible underlying mechanism." @default.
• W3153731385 created "2021-04-26" @default.
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• W3153731385 date "2021-06-01" @default.
• W3153731385 modified "2023-10-14" @default.
• W3153731385 title "Ivabradine augments high-frequency dynamic gain of the heart rate response to low- and moderate-intensity vagal nerve stimulation under β-blockade" @default.
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• W3153731385 doi "https://doi.org/10.1152/ajpheart.00057.2021" @default.
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