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• W3153743542 endingPage "105161" @default.
• W3153743542 startingPage "105161" @default.
• W3153743542 abstract "The potential for ingestion of copper oxide nanomaterials (CuO NMs) is increasing due to their increased exploitation. Investigation of changes in gene expression allows toxicity to be detected at an early stage of NM exposure and can enable investigation of the mechanism of toxicity. Here, undifferentiated Caco-2 cells, differentiated Caco-2 cells, Caco-2/HT29-MTX (mucus secreting) and Caco-2/Raji B (M cell model) co-cultures were exposed to CuO NMs and copper sulphate (CuSO 4 ) in order to determine their impacts. Cellular responses were measured in terms of production of reactive oxygen species (ROS), the gene expression of an antioxidant (haem oxygenase 1 ( HMOX1 )), the pro-inflammatory cytokine (interleukin 8 ( IL8 )), the metal binding (metallothionein 1A and 2A ( MT1A and MT2A )) and the mucus secreting (mucin 2 ( MUC2 )), as well as HMOX-1 protein level. While CuSO 4 induced ROS production in cells, no such effect was observed for CuO NMs. However, these particles did induce an increase in the level of HMOX-1 protein and upregulation of HMOX1 , MT2A , IL8 and MUC2 genes in all cell models. In conclusion, the expression of HMOX1 , IL8 and MT2A were responsive to CuO NMs at 4 to 12 h post exposure when investigating the toxicity of NMs using intestinal in vitro models. These findings can inform the selection of endpoints, timepoints and models when investigating NM toxicity to the intestine in vitro in the future. • Toxicity of CuO NMs was investigated using four intestinal in vitro models. • Single cell cultures were more sensitive to CuO NM toxicity than more complex co-culture models • CuO NMs stimulated upregulation of antioxidant and proinflammatory response genes across all models. • Metal binding and mucus secreting genes were also upregulated by CuO NMs." @default.
• W3153743542 created "2021-04-26" @default.
• W3153743542 creator A5008390045 @default.
• W3153743542 creator A5020231507 @default.
• W3153743542 creator A5030449236 @default.
• W3153743542 creator A5032981829 @default.
• W3153743542 date "2021-08-01" @default.
• W3153743542 modified "2023-09-27" @default.
• W3153743542 title "Time dependent impact of copper oxide nanomaterials on the expression of genes associated with oxidative stress, metal binding, inflammation and mucus secretion in single and co-culture intestinal in vitro models" @default.
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