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- W315375892 abstract "Altered cholesterol homeostasis in general and increased levels of low-density lipoprotein (LDL) cholesterol specifically is a robust risk factor for the pathogenesis of sporadic Alzheimer's disease (AD). Because of this, the family of drugs known as statins have been tried extensively to lower cholesterol levels in attempting to prevent and/or lessen the neuropathogenesis of AD. Unfortunately, evidence accumulated to date is insufficient to support the continued use of statins as a viable pharmacotherapeutic approach against AD. To understand these complex and inter-related issues it is important to review how altered cholesterol homeostasis contributes to AD pathogenesis and why statins have not provided clinical benefit against AD. Apolipoproteins with their different affinities for various lipids and the receptors that control cholesterol uptake can result in drastic differences in cholesterol trafficking into and its distribution within neurons. The presence of the apoE4 or elevated plasma levels of LDL cholesterol can lead to a set of conditions that resembles lysosomal lipid storage disorders observed in Niemann-Pick type C disease such as impaired recycling of cholesterol back to the endoplasmic reticulum (ER), Golgi and plasma membranes, cholesterol deficiencies in plasma membranes, and increased cholesterol accumulation in endolysosomes resulting in endolysosome dysfunction. Consequently, the use of statins to block cholesterol synthesis in ER might not only decrease further plasma membrane cholesterol levels thus disturbing synaptic integrity, but also could also increase cholesterol burden in endolysosomes thus worsening endolysosome dysfunction. Therefore, it is not surprising that the use of cholesterol-lowering strategies with statins has not resulted in clinical benefit for patients living with AD." @default.
- W315375892 created "2016-06-24" @default.
- W315375892 creator A5012132969 @default.
- W315375892 creator A5068269611 @default.
- W315375892 creator A5074631924 @default.
- W315375892 date "2014-08-26" @default.
- W315375892 modified "2023-10-18" @default.
- W315375892 title "Role of endolysosomes and cholesterol in the pathogenesis of Alzheimer's disease: Insights into why statins might not provide clinical benefit." @default.
- W315375892 cites W125508901 @default.
- W315375892 cites W1524901037 @default.
- W315375892 cites W1533505805 @default.
- W315375892 cites W1549799773 @default.
- W315375892 cites W1663752251 @default.
- W315375892 cites W18034176 @default.
- W315375892 cites W1822725522 @default.
- W315375892 cites W1892400228 @default.
- W315375892 cites W1897920860 @default.
- W315375892 cites W1963021413 @default.
- W315375892 cites W1969151806 @default.
- W315375892 cites W1969709596 @default.
- W315375892 cites W1970541648 @default.
- W315375892 cites W1970929051 @default.
- W315375892 cites W1974808250 @default.
- W315375892 cites W1975096688 @default.
- W315375892 cites W1976541189 @default.
- W315375892 cites W1977451676 @default.
- W315375892 cites W1977960636 @default.
- W315375892 cites W1978993923 @default.
- W315375892 cites W1979995395 @default.
- W315375892 cites W1980323811 @default.
- W315375892 cites W1982686316 @default.
- W315375892 cites W1983985535 @default.
- W315375892 cites W1984737558 @default.
- W315375892 cites W1985623563 @default.
- W315375892 cites W1986154972 @default.
- W315375892 cites W1986228536 @default.
- W315375892 cites W1990752558 @default.
- W315375892 cites W1992515094 @default.
- W315375892 cites W1993668532 @default.
- W315375892 cites W1994090868 @default.
- W315375892 cites W1994344429 @default.
- W315375892 cites W2005060496 @default.
- W315375892 cites W2005483591 @default.
- W315375892 cites W2008790098 @default.
- W315375892 cites W2009230396 @default.
- W315375892 cites W2012221575 @default.
- W315375892 cites W2012636408 @default.
- W315375892 cites W2012894757 @default.
- W315375892 cites W2017196579 @default.
- W315375892 cites W2023713823 @default.
- W315375892 cites W2028199124 @default.
- W315375892 cites W2031762899 @default.
- W315375892 cites W2033460128 @default.
- W315375892 cites W2036362108 @default.
- W315375892 cites W2037500564 @default.
- W315375892 cites W2037532481 @default.
- W315375892 cites W2038003980 @default.
- W315375892 cites W2040365078 @default.
- W315375892 cites W2041559439 @default.
- W315375892 cites W2042421739 @default.
- W315375892 cites W204382828 @default.
- W315375892 cites W2045372790 @default.
- W315375892 cites W2045548994 @default.
- W315375892 cites W2046054972 @default.
- W315375892 cites W2047972989 @default.
- W315375892 cites W2049658781 @default.
- W315375892 cites W2050290378 @default.
- W315375892 cites W2050293051 @default.
- W315375892 cites W2051765035 @default.
- W315375892 cites W2053525596 @default.
- W315375892 cites W2054595666 @default.
- W315375892 cites W2059071540 @default.
- W315375892 cites W2063300877 @default.
- W315375892 cites W2068572021 @default.
- W315375892 cites W2070539978 @default.
- W315375892 cites W2071561134 @default.
- W315375892 cites W2074561520 @default.
- W315375892 cites W2076533476 @default.
- W315375892 cites W2076965707 @default.
- W315375892 cites W2081415721 @default.
- W315375892 cites W2082429191 @default.
- W315375892 cites W2082438601 @default.
- W315375892 cites W2083403430 @default.
- W315375892 cites W2083625312 @default.
- W315375892 cites W2085831929 @default.
- W315375892 cites W2085939493 @default.
- W315375892 cites W2087447309 @default.
- W315375892 cites W2090271811 @default.
- W315375892 cites W2091017147 @default.
- W315375892 cites W2091098404 @default.
- W315375892 cites W2094894558 @default.
- W315375892 cites W2094915473 @default.
- W315375892 cites W2095801584 @default.
- W315375892 cites W2096584150 @default.
- W315375892 cites W2096590285 @default.
- W315375892 cites W2101675738 @default.
- W315375892 cites W2102580489 @default.
- W315375892 cites W2106516020 @default.
- W315375892 cites W2110649177 @default.
- W315375892 cites W2110747905 @default.