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- W3153770596 abstract "Previous research has found that miRNA-20b is highly expressed in gastric cancer (GC), however, its function and underlying mechanism are not clear. Wnt signaling pathway, implicated in tumorigeneisis, is activated in more than 30% of GC. We would like to characterize the biological behavior of miRNA-20b in terms of modulating Wnt/β-catenin signaling and EMT. We showed that miRNA-20b inhibitors suppressed Topflash/Fopflash dependent luciferase activity and the β-catenin nuclear translocation, resulting in inhibition of Wnt pathway activity and EMT. SUFU, negatively regulating Wnt and Hedgehog signaling pathway, was proved to be targeted by miRNA-20b. Moreover, additional knockdown of SUFU alleviated the inhibitory effect on Wnt pathway activity, EMT, cell proliferation/migration and colony formation caused by miRNA-20b inhibition.In summary, miRNA-20b is an oncogenic miRNA and promoted cell proliferation, migration and EMT in GC partially by activating Wnt pathway via targeting SUFU." @default.
- W3153770596 created "2021-04-26" @default.
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- W3153770596 date "2021-04-01" @default.
- W3153770596 modified "2023-10-18" @default.
- W3153770596 title "MiRNA-20b/SUFU/Wnt axis accelerates gastric cancer cell proliferation, migration and EMT" @default.
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- W3153770596 doi "https://doi.org/10.1016/j.heliyon.2021.e06695" @default.
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