FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3153776791> ?p ?o ?g. }

• W3153776791 abstract "Antipsychotics often cause tardive dyskinesia, an adverse symptom of involuntary hyperkinetic movements. Analysis of the US Food and Drug Administration Adverse Event Reporting System and JMDC insurance claims revealed that acetaminophen prevented the dyskinesia induced by dopamine D2 receptor antagonists. In vivo experiments further showed that a 21-day treatment with haloperidol increased the number of vacuous chewing movements (VCMs) in rats, an effect that was inhibited by oral acetaminophen treatment or intracerebroventricular injection of N-(4-hydroxyphenyl)-arachidonylamide (AM404), an acetaminophen metabolite that acts as an activator of the transient receptor potential vanilloid 1 (TRPV1). In mice, haloperidol-induced VCMs were also mitigated by treatment with AM404 applied to the dorsal striatum, an effect not seen in TRPV1-deficient mice. Acetaminophen prevented the haloperidol-induced decrease in the number of c-Fos+preproenkephalin+ striatal neurons in wild-type mice but not in TRPV1-deficient mice. Finally, chemogenetic stimulation of indirect pathway medium spiny neurons in the dorsal striatum decreased haloperidol-induced VCMs. These results suggest that acetaminophen activates the indirect pathway neurons by activating TRPV1 channels via AM404." @default.
• W3153776791 created "2021-04-26" @default.
• W3153776791 creator A5004100710 @default.
• W3153776791 creator A5004402168 @default.
• W3153776791 creator A5012323572 @default.
• W3153776791 creator A5012487815 @default.
• W3153776791 creator A5017513976 @default.
• W3153776791 creator A5018307253 @default.
• W3153776791 creator A5031889786 @default.
• W3153776791 creator A5036565456 @default.
• W3153776791 creator A5037346718 @default.
• W3153776791 creator A5052436950 @default.
• W3153776791 creator A5056412472 @default.
• W3153776791 creator A5078967543 @default.
• W3153776791 creator A5080973494 @default.
• W3153776791 creator A5081587450 @default.
• W3153776791 date "2021-05-24" @default.
• W3153776791 modified "2023-10-16" @default.
• W3153776791 title "Striatal TRPV1 activation by acetaminophen ameliorates dopamine D2 receptor antagonist–induced orofacial dyskinesia" @default.
• W3153776791 cites W1965252147 @default.
• W3153776791 cites W1966403223 @default.
• W3153776791 cites W1967558194 @default.
• W3153776791 cites W1969043927 @default.
• W3153776791 cites W1971079627 @default.
• W3153776791 cites W1977748966 @default.
• W3153776791 cites W1988252969 @default.
• W3153776791 cites W1996486545 @default.
• W3153776791 cites W2005828463 @default.
• W3153776791 cites W2024057818 @default.
• W3153776791 cites W2026036833 @default.
• W3153776791 cites W2035521645 @default.
• W3153776791 cites W2044632947 @default.
• W3153776791 cites W2050519455 @default.
• W3153776791 cites W2050781058 @default.
• W3153776791 cites W2055562826 @default.
• W3153776791 cites W2059973492 @default.
• W3153776791 cites W2066998519 @default.
• W3153776791 cites W2091298068 @default.
• W3153776791 cites W2111635289 @default.
• W3153776791 cites W2155694557 @default.
• W3153776791 cites W2171260594 @default.
• W3153776791 cites W2304426385 @default.
• W3153776791 cites W2406299101 @default.
• W3153776791 cites W2408641126 @default.
• W3153776791 cites W2523277423 @default.
• W3153776791 cites W2556159257 @default.
• W3153776791 cites W2582061582 @default.
• W3153776791 cites W2589851064 @default.
• W3153776791 cites W2735203462 @default.
• W3153776791 cites W2741122507 @default.
• W3153776791 cites W2770313854 @default.
• W3153776791 cites W2771918145 @default.
• W3153776791 cites W2902092068 @default.
• W3153776791 cites W2917327765 @default.
• W3153776791 cites W2942690310 @default.
• W3153776791 cites W2967563100 @default.
• W3153776791 cites W2996268915 @default.
• W3153776791 cites W3002680638 @default.
• W3153776791 cites W3018681153 @default.
• W3153776791 cites W47558492 @default.
• W3153776791 doi "https://doi.org/10.1172/jci.insight.145632" @default.
• W3153776791 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/8262333" @default.
• W3153776791 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/33857021" @default.
• W3153776791 hasPublicationYear "2021" @default.
• W3153776791 type Work @default.
• W3153776791 sameAs 3153776791 @default.
• W3153776791 citedByCount "8" @default.
• W3153776791 countsByYear W31537767912022 @default.
• W3153776791 countsByYear W31537767912023 @default.
• W3153776791 crossrefType "journal-article" @default.
• W3153776791 hasAuthorship W3153776791A5004100710 @default.
• W3153776791 hasAuthorship W3153776791A5004402168 @default.
• W3153776791 hasAuthorship W3153776791A5012323572 @default.
• W3153776791 hasAuthorship W3153776791A5012487815 @default.
• W3153776791 hasAuthorship W3153776791A5017513976 @default.
• W3153776791 hasAuthorship W3153776791A5018307253 @default.
• W3153776791 hasAuthorship W3153776791A5031889786 @default.
• W3153776791 hasAuthorship W3153776791A5036565456 @default.
• W3153776791 hasAuthorship W3153776791A5037346718 @default.
• W3153776791 hasAuthorship W3153776791A5052436950 @default.
• W3153776791 hasAuthorship W3153776791A5056412472 @default.
• W3153776791 hasAuthorship W3153776791A5078967543 @default.
• W3153776791 hasAuthorship W3153776791A5080973494 @default.
• W3153776791 hasAuthorship W3153776791A5081587450 @default.
• W3153776791 hasBestOaLocation W31537767911 @default.
• W3153776791 hasConcept C118552586 @default.
• W3153776791 hasConcept C126322002 @default.
• W3153776791 hasConcept C134018914 @default.
• W3153776791 hasConcept C155164980 @default.
• W3153776791 hasConcept C160145004 @default.
• W3153776791 hasConcept C170493617 @default.
• W3153776791 hasConcept C185592680 @default.
• W3153776791 hasConcept C2776412080 @default.
• W3153776791 hasConcept C2778722691 @default.
• W3153776791 hasConcept C2779134260 @default.
• W3153776791 hasConcept C2779158372 @default.
• W3153776791 hasConcept C2779734285 @default.
• W3153776791 hasConcept C2780062018 @default.
• W3153776791 hasConcept C2780405171 @default.
• W3153776791 hasConcept C2780948584 @default.

• next