FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3153810008> ?p ?o ?g. }

• W3153810008 endingPage "23" @default.
• W3153810008 startingPage "13" @default.
• W3153810008 abstract "An interactive crosstalk between tumor and stroma cells is essential for metastatic melanoma progression. We evidenced that ESDN/DCBLD2/CLCP1 plays a crucial role in endothelial cells during the spread of melanoma. Precisely, increased extravasation and metastasis formation were revealed in ESDN-null mice injected with melanoma cells, even if the primary tumor growth, vessel permeability, and angiogenesis were not enhanced. Interestingly, improved adhesion of melanoma cells to ESDN-depleted endothelial cells was observed, due to the presence of higher levels of E-selectin transcripts/proteins in ESDN-defective cells. In accordance with these results, anticorrelation was observed between ESDN and E-selectin in human endothelial cells. Most importantly, our data revealed that cimetidine, an E-selectin inhibitor, was able to block cell adhesion, extravasation, and metastasis formation in ESDN-null mice, underlying a major role of ESDN in E-selectin transcription upregulation, which according to our data, may presumably be linked to STAT3. Based on our results, we propose a protective role for ESDN during the spread of melanoma and reveal its therapeutic potential." @default.
• W3153810008 created "2021-04-26" @default.
• W3153810008 creator A5008453786 @default.
• W3153810008 creator A5012376450 @default.
• W3153810008 creator A5032327963 @default.
• W3153810008 creator A5032450940 @default.
• W3153810008 creator A5032849872 @default.
• W3153810008 creator A5035458471 @default.
• W3153810008 creator A5040214907 @default.
• W3153810008 creator A5042286463 @default.
• W3153810008 creator A5046627942 @default.
• W3153810008 creator A5046908569 @default.
• W3153810008 creator A5049648750 @default.
• W3153810008 creator A5054632970 @default.
• W3153810008 creator A5062038577 @default.
• W3153810008 creator A5063120064 @default.
• W3153810008 creator A5081131425 @default.
• W3153810008 creator A5082859951 @default.
• W3153810008 creator A5085217700 @default.
• W3153810008 date "2021-07-01" @default.
• W3153810008 modified "2023-10-17" @default.
• W3153810008 title "ESDN inhibits melanoma progression by blocking E-selectin expression in endothelial cells via STAT3" @default.
• W3153810008 cites W1479974475 @default.
• W3153810008 cites W1523735757 @default.
• W3153810008 cites W1976294091 @default.
• W3153810008 cites W1978310782 @default.
• W3153810008 cites W1983774546 @default.
• W3153810008 cites W1985095163 @default.
• W3153810008 cites W1987640672 @default.
• W3153810008 cites W1988466951 @default.
• W3153810008 cites W1989472029 @default.
• W3153810008 cites W1994785454 @default.
• W3153810008 cites W2004433270 @default.
• W3153810008 cites W2005133489 @default.
• W3153810008 cites W2011457604 @default.
• W3153810008 cites W2016987827 @default.
• W3153810008 cites W2022554267 @default.
• W3153810008 cites W2027428724 @default.
• W3153810008 cites W2043015888 @default.
• W3153810008 cites W2043584813 @default.
• W3153810008 cites W2055624262 @default.
• W3153810008 cites W2056000702 @default.
• W3153810008 cites W2056732121 @default.
• W3153810008 cites W2058799772 @default.
• W3153810008 cites W2059921126 @default.
• W3153810008 cites W2061045389 @default.
• W3153810008 cites W2064629866 @default.
• W3153810008 cites W2065442216 @default.
• W3153810008 cites W2066722284 @default.
• W3153810008 cites W2069541017 @default.
• W3153810008 cites W2069854015 @default.
• W3153810008 cites W2073775185 @default.
• W3153810008 cites W2092118786 @default.
• W3153810008 cites W2092823597 @default.
• W3153810008 cites W2098070345 @default.
• W3153810008 cites W2099180770 @default.
• W3153810008 cites W2100239923 @default.
• W3153810008 cites W2103594573 @default.
• W3153810008 cites W2117119768 @default.
• W3153810008 cites W2117692326 @default.
• W3153810008 cites W2127765072 @default.
• W3153810008 cites W2131445723 @default.
• W3153810008 cites W2134471382 @default.
• W3153810008 cites W2139319526 @default.
• W3153810008 cites W2144903567 @default.
• W3153810008 cites W2146053439 @default.
• W3153810008 cites W2150740687 @default.
• W3153810008 cites W2154700978 @default.
• W3153810008 cites W2155555524 @default.
• W3153810008 cites W2163318518 @default.
• W3153810008 cites W2165874501 @default.
• W3153810008 cites W2169503006 @default.
• W3153810008 cites W2209085507 @default.
• W3153810008 cites W2275552236 @default.
• W3153810008 cites W2293228432 @default.
• W3153810008 cites W2313140895 @default.
• W3153810008 cites W2332292689 @default.
• W3153810008 cites W2412007284 @default.
• W3153810008 cites W2465519374 @default.
• W3153810008 cites W2617101437 @default.
• W3153810008 cites W2620162514 @default.
• W3153810008 cites W2773015816 @default.
• W3153810008 cites W2786987313 @default.
• W3153810008 cites W2801937622 @default.
• W3153810008 cites W2940672137 @default.
• W3153810008 cites W2941505882 @default.
• W3153810008 cites W2948566136 @default.
• W3153810008 cites W2967805215 @default.
• W3153810008 cites W2999417355 @default.
• W3153810008 cites W3009614746 @default.
• W3153810008 cites W3014374354 @default.
• W3153810008 cites W4211223138 @default.
• W3153810008 doi "https://doi.org/10.1016/j.canlet.2021.04.005" @default.
• W3153810008 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/8581997" @default.
• W3153810008 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/33862151" @default.
• W3153810008 hasPublicationYear "2021" @default.
• W3153810008 type Work @default.
• W3153810008 sameAs 3153810008 @default.

• next