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• W3153855648 abstract "Abstract Objective Epileptic patients with hypothalamic hamartoma (HH) frequently present cognitive impairments. Surgical techniques aiming at HH can be very efficient for epilepsy relief and cognitive improvement but are also demonstrated to carry a significant risk of additional reduction in memory function in these already disabled patients. Gamma knife radiosurgery (GKS) offers an efficient minimally invasive procedure. We evaluated the effect of stereotactic radiosurgery on cognitive outcome. Methods We designed a prospective single‐center case series study. Thirty‐nine epileptic patients (median age = 17 years, range = 4–50) with HH underwent preoperative and postoperative testing of intelligence quotient (IQ; all patients), including a working memory component, and other memory function testing (for patients ≥16 years old). All patients were prospectively evaluated and underwent complete presurgical and postsurgical clinical, electrophysiological, endocrinal, and visual assessments. In all patients, the postoperative assessment was performed at least 3 years after radiosurgery. We explored what variables correlate with cognitive outcome. Literature review was done for other surgical techniques and their risks for cognitive complications after surgery. Results No decline was observed in intellectual ability (including working memory) after GKS, and no memory decline was seen in adults. We observed significant improvement (>1 SD in z ‐score) in working memory index (46%) and processing speed index (35%), as well as improvement in full‐scale IQ (24%), verbal comprehension index (11%), perceptual organization index (21%), verbal learning (20%), and visual learning (33%). Before GKS, the probability of seizure cessation was higher in patients with higher cognitive performance. After GKS, the cognitive improvement was significantly higher in the seizure‐free patients compared to the non‐seizure‐free patients. Significance We found clear cognitive improvement in a high percentage of patients but importantly no significant decline in intellectual ability (including working memory) and no decline in memory in adult patients 3 years after GKS. GKS compares favorably to the other surgical techniques in terms of cognitive outcome, with similar seizure freedom." @default.
• W3153855648 created "2021-04-26" @default.
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• W3153855648 date "2021-04-20" @default.
• W3153855648 modified "2023-10-18" @default.
• W3153855648 title "Long‐term cognitive outcome after radiosurgery in epileptic hypothalamic hamartomas and review of the literature" @default.
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• W3153855648 doi "https://doi.org/10.1111/epi.16896" @default.
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